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Drug effectiveness study Publications

Drug effectiveness study Publications

  • Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?.Abstract

    BACKGROUND: Metformin, statin and aspirin use seem associated with decreased mortality in cancer patients, though, without adjusting for one another. Independent associations of these drugs with overall mortality after colorectal cancer (CRC) diagnsis within glucose-lowering drugs (GLDs) users were assessed

    Zander s MM, van Herk-Sukel MP, Vissers PA, Herings RM, Haak HR, van dePoll-Franse LV. Br J Cancer. 2015 Jul 28; 113 (3): 403-10.
  • Antibiotic prescribing on admission to patients with pneumonia and prior outpatient antibiotic treatment: a cohort study on clinical outcome.Abstract

    OBJECTIVE: Most pneumonia treatment guidelines recommend that prior outpatient antibiotic treatment should be considered when planning inpatient antibiotic regimen. Our purpose was to study in patients admitted for community-acquired pneumonia theode of continuing antibiotic treatment at the outpatient to inpatient transition and the subsequent clinical course

    van deGarde EM, Natsch S, Prins JM, van der Linden PD. BMJ Open. 2015 5 (2): e006892.
  • Statin use and its effect on all-cause mortality of melanoma patients: a population-based Dutch cohort study.Abstract

    Preclinical data showed anticancer effects of statins in melanoma, but meta-analyses could not demonstrate a reduced melanoma incidence in statin users. Rather than preventing occurrence, statins might reduce growth and metastatic spread of melanoms and ultimately improve survival. In this population-based study, we investigated the relationship between statin use and survival of melanoma patients

    Livingstone E, Hollestein LM, van Herk-Sukel MP, van dePoll-Franse L, Joosse A, Schilling B, Nijsten T, Schaden dorf D, deVries E. Cancer Med. 2014 Oct; 3 (5): 1284-93.
  • Incident cancer risk after the start of aspirin use: results from a Dutch population-based cohort study of low dose aspirin users.Abstract

    Observational and intervention studies suggest that low dose aspirin use may prevent cancer. The objective of this study was to investigate the protective effect of long term low dose aspirin use (

    Hollestein LM, van Herk-Sukel MP, Ruiter R, de Vries E, Mathijssen RH, Wiemer EA, Stijnen T, Coebergh JW, Lemmens VE, Herings RM, Stricker BH, Nijsten T. Int J Cancer. 2014 Jul 1; 135 (1): 157-65.
  • Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon Cancer.Abstract

    IMPORTANCE Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is associated with improved overall survival. Identifying predictive biomarkers of this effect could individualize therapy and decrease toxic effects. OBJECIVE To demonstrate that survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer might depend on HLA class I antigen expression

    Reimers MS, Bastiaannet E, Langley RE, van Eijk R, van Vlierberghe RL, Lemmens VE, van Herk-Sukel MP, van Wezel T, Fodde R, Kuppen PJ, Morreau H, van de Velde CJ, Liefers GJ. JAMA Intern Med. 2014 May 1; 174 (5): 732-9.
  • beta-Blocker use and all-cause mortality of melanoma patients: results from a population-based Dutch cohort study.Abstract

    BACKGROUND: Results from preclinical and observational studies suggest that beta-adrenoreceptor inhibition might influence disease progression of melanoma. PATIENTS AND METHODS: Patients 18years with cutaneous melanoma (Breslow thickness >1mm) regitered in the Eindhoven Cancer Registry between January 1, 1998 and December 31, 2010, who were also registered with PHARMO record linkage system (RLS), were eligible

    Livingstone E, Hollestein LM, van Herk-Sukel MP, van dePoll-Franse L, Nijsten T, Schaden dorf D, deVries E. Eur J Cancer. 2013 Dec; 49 (18): 3863-71.
  • Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care.Abstract

    PURPOSE: To determine whether treatment with nitrofurantoin in women with urinary tract infection (UTI) and renal impairment in primary care is associated with a higher risk of ineffectiveness and/or serious adverse events than in women without renl impairment. METHODS: A cohort of 21,317 women treated with nitrofurantoin and a cohort of 7,926 women treated with trimethoprim, identified from the Pharmo Record Linkage System, were analysed

    Geerts AF, Eppenga WL, Heerdink R, Derijks HJ, Wensing MJ, Egberts TC, DeSmet PA. Eur J Clin Pharmacol. 2013 Sep; 69 (9): 1701-7.
  • Statin treatment and the risk of recurrent pulmonary embolism.Abstract

    AIMS: Patients with idiopathic venous thromboembolism (VTE) have a high recurrence risk during and after stopping anticoagulant treatment. Several studies suggest that treatment with statins reduces the incidence of a first episode of VTE, but dataon the effects in patients with a previous episode are lacking

    Biere-Rafi S, Hutten BA, Squizzato A, Ageno W, Souverein PC, de Boer A, Gerde s VE, Buller HR, Kamphuisen PW. Eur Heart J. 2013 Jun; 34 (24): 1800-6.
  • Aspirin use after diagnosis improves survival in older adults with colon cancer: a retrospective cohort study.Abstract

    OBJECTIVES: To assess survival in relation to aspirin use after diagnosis in older adults with colon cancer. DESIGN: Subgroup analysis of a previously published cohort and retrospective study. SETTING: Individuals registered in the Eindhoven CancerRegistry (ECR) between 1998 and 2007, linked to prescriptions of low-dose aspirin (80 mg) registered in a community pharmacy database

    Reimers MS, Bastiaannet E, van Herk-Sukel MP, Lemmens VE, van den Broek CB, van deVelde CJ, deCraen AJ, Liefers GJ. J Am Geriatr Soc. 2012 Dec; 60 (12): 2232-6.
  • Cholesterol Level Goal Attainment with Statins: Clinical Management Guideline Recommendations versus Management in Actual Clinical Practice.Abstract

    STUDY OBJECTIVES: To compare the cholesterol level goal attainment rates in patients receiving simvastatin doses recommended in clinical practice guidelines and simvastatin doses most frequently prescribed in clinical practice versus other statinst various dose levels, and to assess statin adherence rates in patients receiving all statins

    Heintjes EM, Penning-van Beest FJ, Plat AW, Meerding WJ, Webb K, Sturkenboom MC, Herings RM. Pharmacotherapy. 2012 Jul; 32 (7): 631-41.