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Drug effectiveness study Publications

Drug effectiveness study Publications

  • Use of Aspirin postdiagnosis improves survival for colon cancer patients.Abstract

    Background:The preventive role of non-steroid anti-inflammatory drugs (NSAIDs) and aspirin, in particular, on colorectal cancer is well established. More recently, it has been suggested that aspirin may also have a therapeutic role. Aim of the presnt observational population-based study was to assess the therapeutic effect on overall survival of aspirin/NSAIDs as adjuvant treatment used after the diagnosis of colorectal cancer patients

    Bastiaannet E, Sampieri K, Dekkers OM, deCraen AJ, van Herk-Sukel MP, Lemmens V, van den Broek CB, Coebergh JW, Herings RM, van deVelde CJ, Fodde R, Liefers GJ. Br J Cancer. 2012 Apr 24; 106 (9): 1564-70.
  • Recurrence of urinary tract infections in postmenopausal diabetic women using different antibiotics.Abstract

    Objectives: Postmenopausal women with diabetes mellitus (DM) have an increased incidence of urinary tract infections (UTI) compared to women without DM. The aim of this study is to compare recurrence rates of UTI in postmenopausal women with DM aftr treatment with nitrofurantoin, the agent of first choice following the Dutch guidelines, with two other common prescribed antibiotics trimethoprim and norfloxacin

    Schneeberger C, Stolk RP, de Vries JH, Herings RMC, Geerlings SE. Journal of Diabetes Mellitus. 2012 2 (2): 261-3.
  • Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study.Abstract

    OBJECTIVE: Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult to estimate. Therefore, the objective of this study was tfurther analyze whether, and to what extent, use of metformin is associated with a decreased risk of cancer in a cohort of incident users of metformin compared with users of sulfonylurea derivatives

    Ruiter R, Visser LE, van Herk-Sukel MP, Coebergh JW, Haak HR, Geelhoed-Duijvestijn PH, Straus SM, Herings RM, Stricker BH. Diabetes Care. 2012 Jan; 35 (1): 119-24.
  • Venous thromboembolism prophylaxis after total knee or hip replacement: treatment pattern and outcomes.Abstract

    PURPOSE: To determine the thromboprophylactic treatment pattern and occurrence of venous thromboembolism (VTE), major bleeding, and wound infections in patients undergoing total knee replacement (TKR) or total hip replacement (THR). METHODS: From te PHARMO database, all patients >/= 18 years hospitalized for TKR or THR between January 2003 and September 2008 were selected

    Penning-van Beest FJ, Overbeek JA, Meijer WM, Woodruff K, Jackson J, van der Vis H, van der Linden P, Herings RM. Pharmacoepidemiol Drug Saf. 2011 Sep; 20 (9): 972-8.
  • Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI.Abstract

    Genetic variability has been shown to affect statin responsiveness. Participants from the Utrecht Cardiovascular Pharmacogenetics (UCP) studies were enrolled from a population-based registry of pharmacy records linked to hospital discharge recordsPHARMO) to investigate tagging SNPs within candidate genes involved in the cholesterol lowering pathway for modification of the effectiveness of statins in reducing the risk of myocardial infarction (MI)

    Peters BJ, Pett H, Klungel OH, Stricker BH, Psaty BM, Glazer NL, Wiggins KL, Bis JC, deBoer A, Maitland-van der Zee AH. Atherosclerosis. 2011 Aug; 217 (2): 458-64.
  • Non-selective vs. selective beta-blocker treatment and the risk of thrombo-embolic events in patients with heart failure.Abstract

    AIMS: Heart failure (HF) is associated with a prothrombotic state, resulting in an increased risk for thrombo-embolic events. Studies suggest a reduced prothrombotic state when non-selective beta-blockers relative to selective beta-blockers are givn. We studied the influence of non-selective beta-blockers compared with selective beta-blockers on the occurrence of arterial and venous thrombo-embolic events in patients with HF

    de Peuter OR, Souverein PC, Klungel OH, Buller HR, de Boer A, Kamphuisen PW. Eur J Heart Fail. 2011 Feb; 13 (2): 220-6.
  • Insulin Glargine versus Insulin Detemir: Glycemic Control and Insulin Dose in Type 2 Diabetes Mellitus Patients Using a Medical Record Linkage System in the Netherlands.Abstract

    Background: In randomized controlled trials, patients with type 2 diabetes mellitus required higher doses of insulin detemir than insulin glargine to obtain the same glycemic control. However, this may differ in daily clinical practice.

    Eland IA, Heintjes EM, Houweling L, de Grooth R, Veneman TF, Bouter KP. J Diabetes Metab. 2011 2 (9): 165.
  • Evaluation of smoking cessation drug use and outcomes in the Netherlands.Abstract

    OBJECTIVE: Several pharmacological therapies are available to help smokers quit. The aim was to investigate the utilisation and effectiveness of smoking cessation drugs in daily practice in the Netherlands. METHODS: Subjects aged >/=18 years with apharmacy prescription of varenicline, bupropion, nicotine replacement therapy (NRT) or nortriptyline between March 2007 and September 2008 were identified from the PHARMO data warehouse, which includes drug dispensing, hospitalisation and other data fromapproximately 2

    Penning-van Beest FJ, Overbeek JA, Smulder s M, van Spiegel PI, Meerding WJ, Herings RM. J Med Econ. 2011 14 (1): 124-9.
  • Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction.Abstract

    OBJECTIVE: To investigate the influence of tagging single-nucleotide polymorphisms (SNPs) within candidate genes involved in the putative anti-inflammatory effects of statins on the effectiveness of statins in reducing the risk of myocardial infarcion (MI). METHODS: We conducted a case-control study in a population-based registry of pharmacy records linked to hospital discharge records (PHARMO)

    Peters BJ, Rodin AS, Klungel OH, Stricker BH, deBoer A, Maitland-van der Zee AH. Pharmacogenet Genomics. 2010 Dec; 20 (12): 766-74.
  • Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.Abstract

    PURPOSE: The use of cytochrome P450 2D6-inhibiting drugs (CYP2D6 inhibitors) during tamoxifen treatment leads to a decrease in plasma concentration of endoxifen, the major active tamoxifen metabolite. Concomitant use of CYP2D6 inhibitors, such as slective serotonin reuptake inhibitors, as well as low tamoxifen adherence may negatively impact tamoxifen efficacy in patients with breast cancer

    Dezentje VO, van Blijder veen NJ, Gelder blom H, Putter H, van Herk-Sukel MP, Casparie MK, Egberts AC, Nortier JW, Guchelaar HJ. J Clin Oncol. 2010 May 10; 28 (14): 2423-9.