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Drug effectiveness study Publications

Drug effectiveness study Publications

  • Glycemic control and long-acting insulin analog utilization in patients with type 2 diabetes.Abstract

    INTRODUCTION: The objective was to compare glycemic control, insulin utilization, and body weight in patients with type 2 diabetes (T2D) initiated on insulin detemir (IDet) or insulin glargine (IGlar) in a real-life setting in the Netherlands. METHDS: Insulin-naive patients with T2D, starting treatment with IDet or IGlar between January 1, 2004 and June 30, 2008, were selected from the PHARMO data network

    Heintjes EM, Thomsen TL, Penning-van Beest FJ, Christensen TE, Herings RM. Adv Ther. 2010 Apr; 27 (4): 211-22.
  • Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorder.Abstract

    OBJECTIVES: Administration to rats of mood stabilizers approved for bipolar disorder (BD) downregulates markers of the brain arachidonic acid (AA, 20:4n-6) metabolic cascade, including phospholipase A(2) (PLA(2)) and cyclooxygenase (COX) expressionWe hypothesized that other agents that target the brain AA cascade, nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, also would ameliorate BD symptoms

    Stolk P, Souverein PC, Wilting I, Leufkens HG, Klein DF, Rapoport SI, Heerdink ER. Prostaglandins Leukot Essent Fatty Acids. 2010 Jan; 82 (1): 9-14.
  • Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study.Abstract

    This case-control study investigates the potential chemoprophylactic properties of non-steroidal anti-inflammatory drugs (NSAIDs) on the incidence of cutaneous melanoma (CM). Data were extracted from the Dutch PHARMO pharmacy database and the PALGApathology database. Cases had a primary CM between 1991 and 2004, were >or=18 years, and were observed for 3 years in PHARMO before diagnosis

    Joosse A, Koomen ER, Casparie MK, Herings RM, Guchelaar HJ, Nijsten T. J Invest Dermatol. 2009 Nov; 129 (11): 2620-7.
  • Comparison of incidences of cardiovascular events among new users of different statins: a retrospective observational cohort study.Abstract

    OBJECTIVE: To compare incidences of cardiovascular disease (CVD) in general and myocardial infarction (MI) specifically between new users of different statins in daily practice. DESIGN AND METHODOLOGY: Retrospective observational cohort study. Datawere obtained from the PHARMO Record Linkage System; the PHARMO database contains pharmacy dispensing records of 3 million patients in the Netherlands registered with community pharmacies, linked to hospitalisation records

    Heintjes EM, Penning-van Beest FJ, Johansson S, Stalenhoef AF, Herings RM. Curr Med Res Opin. 2009 Nov; 25 (11): 2621-9.
  • Melanoma incidence and exposure to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.Abstract

    A reduced incidence of nonmelanoma skin cancer among users of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARb) has been reported. A similar effect is suggested for cutaneous melanoma. We aimed to investigate te possible association between use of ACEi and ARb and the risk of cutaneous melanoma

    Koomen ER, Herings RM, Guchelaar HJ, Nijsten T. Cancer Epidemiol. 2009 Nov; 33 (5): 391-5.
  • Withdrawal of statins and risk of subarachnoid hemorrhage.Abstract

    BACKGROUND AND PURPOSE: Vascular endothelium, which can be affected by statins, is believed to play a substantial role in subarachnoid hemorrhage (SAH). Our objective was to estimate the association between use and withdrawal of statins and the risof SAH. METHODS: We conducted a population-based case-control study within the PHARMO database

    Risselada R, Straatman H, van Kooten F, Dippel DW, van der Lugt A, Niessen WJ, Firouzian A, Herings RM, Sturkenboom MC. Stroke. 2009 Aug; 40 (8): 2887-92.
  • Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study.Abstract

    OBJECTIVES: The risk of a subsequent exacerbation after treatment of an exacerbation with oral corticosteroids without (OS) or with (OSA) antibiotics was evaluated in a historical population based cohort study comprising patients using maintenanceedication for obstructive lung disease. METHODS: The Pharmo database includes drug dispensing records of more than 2 million subjects in The Netherlands

    Roede BM, Bresser P, Binde ls PJ, Kok A, Prins M, terRiet G, Geskus RB, Herings RM, Prins JM. Thorax. 2008 Nov; 63 (11): 968-73.
  • Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant.Abstract

    INTRODUCTION: The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI). Therefore, we assessed whether the effectiveness of statins in reducing the risk of MI wamodified by the GNB3 C825T polymorphism. METHODS: In a population-based registry of pharmacy records linked to hospital discharge records (PHARMO), we used a nested case-control design

    Peters BJ, Maitland-van der Zee AH, Stricker BH, van Wieren-deWijer DB, deBoer A, Kroon AA, deLeeuw PW, Schiffers P, Janssen RG, van Duijn CM, Klungel OH. Pharmacogenet Genomics. 2008 Jul; 18 (7): 631-6.
  • Differences in the pattern of antibiotic prescription profile and recurrence rate for possible urinary tract infections in women with and without diabetes.Abstract

    OBJECTIVE: Women with diabetes have a high incidence and complication rate of urinary tract infections (UTIs). Our aims were to compare current treatment strategies with respect to recurrence rates in women with diabetes with those without diabetesRESEARCH DESIGN AND METHODS: We used a Dutch registration database containing pharmacy dispensing data

    Schneeberger C, Stolk RP, Devries JH, Schneeberger PM, Herings RM, Geerlings SE. Diabetes Care. 2008 Jul; 31 (7): 1380-5.
  • Effect on non-persistent use of oral glucose-lowering drugs on HbA1c goal attainment.Abstract

    Objectives: The aim of this study was to quantify the effect of non-persistence with oral glucose-lowering drugs (OGLD) on HbA1c goal attainment (< 7%) in daily practice.

    Penning-van Beest FJA, van der Bij S, Erkens JA, Kessabi S, Groot M, Herings RM. Curr Med Res Opin. 2008 July; 24 (9): 2523-2529.