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Disease surveillance Publications

Disease surveillance Publications

  • Cardiovascular comorbidities among patients with metastatic colorectal cancer.Abstract

    Aim: As comorbidities may impact treatment decisions, prognoses and quality of care, this study determined the rate of comorbid cardiovascular diseases in patients with metastatic colorectal cancer (mCRC). Methods: From the PHARMO Record Linkage Sytem in The Netherlands, all patients with a hospital discharge code for CRC and distant metastasis from 2000-2008 were selected

    Overbeek JA, Zhao Z, van Herk-Sukel MP, Barber BL, Herings R. Journal of Cancer Therapeutics & Research. 2012 online.
  • Myocardial infarction, ischaemic stroke and pulmonary embolism before and after breast cancer hospitalisation. A population-based study.Abstract

    We studied the occurrence of myocardial infarction (MI), ischaemic stroke (IS) and pulmonary embolism (PE) before and after breast cancer hospitalisation compared with cancer-free controls. For this, women with a first breast cancer hospitalisationduring 2000-2007 were selected from the PHARMO Record Linkage System, including drug use and hospitalisations of three million inhabitants in the Netherlands, and matched 1:10 by age to cancer-free women

    van Herk-Sukel MP, Shantakumar S, Kamphuisen PW, Penning-van Beest FJ, Herings RM. Thromb Haemost. 2011 Jul; 106 (1): 149-55.
  • Time-trends in treatment and cardiovascular events in patients with heart failure: a pharmacosurveillance study.Abstract

    AIMS: We assessed, in patients with a first hospitalization for heart failure (HF), the temporal relationship of the incidence of cardiovascular events, all-cause mortality, and cardiovascular drug treatment. METHODS AND RESULTS: Data were obtainedfrom the PHARMO Record Linkage System, a population-based registry of pharmacy records linked with hospital discharge records in The Netherlands

    de Peuter OR, Lip GY, Souverein PC, Klungel OH, de Boer A, Buller HR, Kamphuisen PW. Eur J Heart Fail. 2011 May; 13 (5): 489-95.
  • Dupuytren’s contracture: a retrospective database analysis to determine hospitalizations in the Netherlands.Abstract

    ABSTRACT: BACKGROUND: Dupuytren’s contracture is a condition of the palmar fascia involving contractures of the fascia and skin in the hand. Current treatment for Dupuytren’s contracture is mainly limited to surgery. In the Netherlands, little is kown about the prevalence of Dupuytren’s contracture. In this study we determined the prevalence of patients with a hospitalization for Dupuytren’s contracture in the Netherlands and characterized their (re)hospitalizations

    Overbeek JA, Penning-van Beest FJ, Heintjes EM, Gerber RA, Cappelleri JC, Hovius SE, Herings RM. BMC Res Notes. 2011 4 402.
  • The risk for breast cancer is not evidently increased in women with hyperprolactinemia.Abstract

    The question has been raised whether hyperprolactinemia in humans is associated with an excess risk for breast cancer. We aimed to assess the risk of breast cancer in a previously defined large cohort of patients treated for idiopathic hyperprolactnemia or prolactinomas. Based on the pattern of drug prescriptions we identified 11,314 subjects in the PHARMO network with at least one dispensing of dopamine agonists between 1996 and 2006

    Dekkers OM, Romijn JA, deBoer A, Vanden broucke JP. Pituitary. 2010 Sep; 13 (3): 195-8.
  • Psoriasis may not be an independent risk factor for acute ischemic heart disease hospitalizations: results of a large population-based Dutch cohort.Abstract

    Although psoriasis has been associated with components of the metabolic syndrome, its association with myocardial infarction is less clear. A cohort study was conducted using hospital and pharmacy records of 2.5 million Dutch residents between 1997and 2008. The risk of ischemic heart disease (IHD) hospitalizations was compared between psoriasis patients and a matched reference cohort

    Wakkee M, Herings RM, Nijsten T. J Invest Dermatol. 2010 Apr; 130 (4): 962-7.
  • Risk of hip/femur fracture after stroke: a population-based case-control study.Abstract

    BACKGROUND AND PURPOSE: Stroke increases the risk of hip/femur fracture, as seen in several studies, although the time course of this increased risk remains unclear. Therefore, our purpose is to evaluate this risk and investigate the time course ofany elevated risk. METHODS: We conducted a case-control study using the Dutch PHARMO Record Linkage System database

    Pouwels S, Lalmohamed A, Leufkens B, de Boer A, Cooper C, van Staa T, de Vries F. Stroke. 2009 Oct; 40 (10): 3281-5.
  • Estimated age- and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia.Abstract

    CONTEXT: Few data exist on sex- and age-specific incidence and prevalence of idiopathic hyperprolactinemia and prolactinomas. OBJECTIVES: Our objective was to assess incidence and prevalence of dopamine agonist-treated hyperprolactinemia by age andsex. DESIGN: From the PHARMO network, we identified an open cohort of patients who were ever dispensed dopamine agonists for hyperprolactinemia

    Kars M, Souverein PC, Herings RM, Romijn JA, Vanden broucke JP, deBoer A, Dekkers OM. J Clin Endocrinol Metab. 2009 Aug; 94 (8): 2729-34.
  • Extent of uncontrolled disease and associated medical costs in severe asthma–a PHARMO study.Abstract

    OBJECTIVE: Asthma is a major public health problem with considerable economic impact. The highest costs being observed in patients with severe asthma. Furthermore, despite the use of recommended therapies, asthma control can still be poor. Therefor, the objective of this study was to assess the extent of uncontrolled disease and associated medical costs in severe asthma

    Breekveldt-Postma NS, Erkens JA, Aalbers R, van de Ven MJ, Lammers JW, Herings RM. Curr Med Res Opin. 2008 Apr; 24 (4): 975-983.
  • Developments of the incidence of osteoporosis in The Netherlands: a PHARMO study.Abstract

    PURPOSE: To assess recent and to predict future time trends in the incidence of osteoporosis using routine databases in The Netherlands in the period 1993-2015 and to compare estimations based on hip fractures versus a proxy based on pharmacy and hspitalisation data. METHODS: The incidence of hip fractures was estimated over the period 1986-2002 using information from the Dutch Medical Registry, covering more than 99% of all Dutch hospitalisations

    Goettsch WG, de Jong RB, Kramarz P, Herings RM. Pharmacoepidemiol Drug Saf. 2007 Feb; 16 (2): 166-72.