Respiratory diseases – Page 3

Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study

OBJECTIVES: The risk of a subsequent exacerbation after treatment of an exacerbation with oral corticosteroids without (OS) or with (OSA) antibiotics was evaluated in a historical population based cohort study comprising patients using maintenanceedication for obstructive lung disease. METHODS: The Pharmo database includes drug dispensing records of more than 2 million subjects in The Netherlands

1 November 2008

Extent of uncontrolled disease and associated medical costs in severe asthma–a PHARMO study

OBJECTIVE: Asthma is a major public health problem with considerable economic impact. The highest costs being observed in patients with severe asthma. Furthermore, despite the use of recommended therapies, asthma control can still be poor. Therefor, the objective of this study was to assess the extent of uncontrolled disease and associated medical costs in severe asthma

1 April 2008

Antipsychotic drug use and risk of pneumonia in elderly people

OBJECTIVES: To investigate the association between antipsychotic drug use and risk of pneumonia in elderly people. DESIGN: A nested case-control analysis. SETTING: Data were used from the PHARMO database, which collates information from community parmacies and hospital discharge records. PARTICIPANTS: A cohort of 22,944 elderly people with at least one antipsychotic prescription; 543 cases of hospital admission for pneumonia were identified

1 April 2008

Treatment with inhaled corticosteroids in asthma is too often discontinued

PURPOSE: To study persistence with inhaled corticosteroids (ICS) and its determinants in asthma-patients. METHODS: From the PHARMO database, asthma-patients (age < 35 years) with a first dispensing for ICS in 1999-2002 and >/= 2 dispensings in theirst year were included. Persistence during the first year was defined as the number of days from start to time of first failure to continue renewal of the initial ICS

1 April 2008

Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction

BACKGROUND: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein. OBJECTIVES: To examine the association between the use of inhaled corticosteroidsand the risk of non-fatal acute MI. METHODS: In the Dutch PHARMO record linkage system database, we conducted a case-control study (2476 MI cases), nested in a cohort of antihypertensive drug users

1 January 2008

Enhanced persistence with tiotropium compared with other respiratory drugs in COPD

BACKGROUND: Tiotropium is a once-daily inhaled anticholinergic maintenance treatment with demonstrated effectiveness in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To compare persistence of tiotropium-use with other inhaled respiratorydrugs in COPD in current clinical practice. METHODS: The PHARMO database includes, among others, drug-dispensing and hospital discharge records for 2 million subjects in the Netherlands

1 July 2007

Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study

INTRODUCTION: Administration of beta-2 agonists decreased bone mineral density in rats. But the association between bronchodilators and fracture risk has not been studied in humans. OBJECTIVES: To examine the association between use of beta-2 agonits and risk of hip/femur fracture. METHODS: We conducted a population-based case-control study (6763 cases) in the Dutch PHARMO database

1 June 2007

Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence

BACKGROUND: In order to accurately distinguish gaps of varying length in drug treatment for chronic conditions from discontinuation without resuming therapy, short-term observation does not suffice. Thus, the use of inhalation corticosteroids (ICS)in the long-term, during a ten-year period is investigated

1 January 2007

Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population

The aim of the present study was to assess whether the use of angiotensin-converting enzyme (ACE) inhibitors is associated with a decreased risk of hospitalisation for community-acquired pneumonia (CAP) in a general, essentially white population. Dta were obtained from the Dutch PHARMO Record Linkage System

1 June 2006

Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study

Extent of uncontrolled disease and associated medical costs in severe asthma–a PHARMO study

Antipsychotic drug use and risk of pneumonia in elderly people

Treatment with inhaled corticosteroids in asthma is too often discontinued

Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction

Enhanced persistence with tiotropium compared with other respiratory drugs in COPD

Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study

Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence

Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population

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