All Publications

• Prescribing pattern of antipsychotic drugs during the years 1996-2010: a population-based database study in Europe with a focus on torsadogenic drugsAbstract

  INTRODUCTION: Antipsychotic drugs (APDs) are used to treat several mental illnesses. Some APDs have long been known to be associated with QT prolongation, potentially leading to torsades de pointes (TdP) and sudden cardiac death (SCD). In 2005, thiridazine was withdrawn because of the risk of SCD, bringing further attention to the arrhythmogenic potential of APDs

  Oteri A, Mazzaglia G, Pecchioli S, Molokhia M, Ulrichsen SP, Peder sen L, Poluzzi E, DePonti F, Garbe E, Schink T, Herings R, Bezemer ID, Sturkenboom MC, Trifiro G. Br J Clin Pharmacol. 2016 Aug; 82 (2): 487-97.

• Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel-proton pump inhibitor interactionAbstract

  Safety concerns of the concomitant use of clopidogrel-proton pump inhibitors (PPIs) were published in 2009 and 2010 by the medicines regulatory agencies, including a direct healthcare professional communication. We examined the association between various safety statements and prescription behavior for gastroprotective drugs in naive patients in the Netherlands during the years 2008-2011

  Pharmacology Research & Perspectives. July 18; 4 (4): e00242.

• Post authorization safety study comparing quetiapine to risperidone and olanzapineAbstract

  OBJECTIVES: To compare rates of specific adverse outcomes between patients starting quetiapine, olanzapine, or risperidone use in the Netherlands. METHODS: Observational study using the PHARMO Database Network, including patients starting quetiapin(4658), olanzapine (5856), or risperidone (7229) in 2000-2009, comparing rates of all-cause mortality, failed suicide attempts, extrapyrimidal symptoms (EPS), diabetes mellitus (DM), hypothyroidism, and acute myocardial infarction (AMI)

  Heintjes EM, Overbeek JA, Penning-van Beest FJ, Brobert G, Herings RM. Hum Psychopharmacol. 2016 Jul; 31 (4): 304-12.

• Risk of cardiac valvulopathy with use of bisphosphonates: a population-based, multi-country case-control studyAbstract

  Analyses of healthcare data from 30 million individuals in three countries showed that current use of bisphosphonates may be associated with a small increased risk of cardiac valvulopathy (vs. those not exposed within the previous year), although cnfounding cannot be entirely ruled out. The observed tendency for decreased valvulopathy risk with cumulative duration of bisphosphonate use >6 months may even indicate a protective effect with prolonged use

  Coloma PM, deRidder M, Bezemer I, Herings RM, Gini R, Pecchioli S, Scotti L, Rijnbeek P, Mosseveld M, van der Lei J, Trifiro G, Sturkenboom M, Consortium Eu-Adr. Osteoporos Int. 2016 May; 27 (5): 1857-67.

• Musculoskeletal Hospital Admission and Surgical Procedure Rates among Patients Treated for Rheumatoid Arthritis in the Netherlands 1999-2012Abstract

  Objectives: To assess trends in hospitalizations among patients receiving rheumatoid arthritis (RA)-treatment in a 13-year period compared with population references.

  Bezemer ID, Kool-Houweling LMA, Alemao E, Penning-van Beest FJA, Herings RMC. J Orthopedics Rheumatol. 2016 April; 3 (1):

• The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patientsAbstract

  BACKGROUND: Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. MEHODS: Patients with oesophageal cancer (1998-2010) were selected from the Eindhoven Cancer Registry and linked with outpatient pharmacy data regarding aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)

  van Staalduinen J, Frouws M, Reimers M, Bastiaannet E, van Herk-Sukel MP, Lemmens V, de Steur WO, Hartgrink HH, van de Velde CJ, Liefers GJ. Br J Cancer. 2016 Apr 26; 114 (9): 1053-9.

• Oral and inhaled corticosteroid use and risk of recurrent pulmonary embolismAbstract

  INTRODUCTION: Chronic inflammatory diseases predispose for development of a first pulmonary embolism (PE). Previous studies showed that corticosteroids, which are the mainstay of treatment for inflammatory diseases, enhance the risk of a first venos thromboembolism. Yet, it is unknown whether corticosteroids also predispose for recurrent events

  Sneeboer MM, Hutten BA, Majoor CJ, Bel EH, Kamphuisen PW. Thromb Res. 2016 Feb 12; 140 46-50.

• Increasing trends in the incidence and prevalence rates of type 1 diabetes among children and adolescents in the NetherlandsAbstract

  OBJECTIVE: To assess the trends in the incidence and prevalence rates of type 1 diabetes (T1D) among children and adolescents in the Netherlands. METHODS: A population-based cohort study was conducted in the Dutch PHARMO record linkage system (19982011). All children and adolescents aged

  FazeliFarsani S, Souverein PC, van der Vorst MM, Knibbe CA, Herings RM, deBoer A, Mantel-Teeuwisse AK. Pediatr Diabetes. 2016 Feb; 17 (1): 44-52.

• Use of oral contraceptives in three European countries: a population-based multi-database studyAbstract

  OBJECTIVES: The aim of the study was to assess the prevalence of oral contraceptive (OC) use, user characteristics and prescribing patterns by accessing health care databases of three European countries. METHODS: A retrospective study was performedfrom 2009 to 2010 in three general practice (GP) databases from the Netherlands, UK and Italy and in one database of linked pharmacy and hospitalisation data in the Netherlands

  Bezemer ID, Verhamme KM, Gini R, Mosseveld M, Rijnbeek PR, Trifiro G, Sturkenboom MC, Penning-van Beest FJ, Herings RM. Eur J Contracept Reprod Health Care. 2016 Feb; 21 (1): 81-7.

• Rates of prostate surgery and acute urinary retention for benign prostatic hyperplasia in men treated with dutasteride or finasterideAbstract

  BACKGROUND: Previous studies have suggested a greater benefit for various outcomes in men diagnosed with benign prostatic hyperplasia (BPH) who are treated with dutasteride than for men treated with finasteride. This study investigates whether theates of BPH-related prostate surgery and acute urinary retention (AUR) differ between dutasteride and finasteride users in the Netherlands

  Kuiper JG, Bezemer ID, Driessen MT, Vasylyev A, Roehrborn CG, Penning-van Beest FJ, Herings RM. BMC Urol. 2016 16 (1): 53.