Publications – Page 9

Determination of non-treatment with statins of high risk patients in The Netherlands

OBJECTIVE: To determine in the Netherlands what proportions of high risk patients with established cardiovascular disease (CVD) or diabetes mellitus type 2 (DM2) who were not treated with statins on 1 January 2007 and which characteristics were assciated with non-treatment. METHODS: From the IPCI GP database patients were selected who were registered with a GP on 1 January 2007 who had a history of either CVD (CVD patients), DM2 (diabetics) or both (diabetics with CVD)

1 February 2010

Melanoma incidence and exposure to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers

A reduced incidence of nonmelanoma skin cancer among users of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARb) has been reported. A similar effect is suggested for cutaneous melanoma. We aimed to investigate te possible association between use of ACEi and ARb and the risk of cutaneous melanoma

1 November 2009

Comparison of incidences of cardiovascular events among new users of different statins: a retrospective observational cohort study

OBJECTIVE: To compare incidences of cardiovascular disease (CVD) in general and myocardial infarction (MI) specifically between new users of different statins in daily practice. DESIGN AND METHODOLOGY: Retrospective observational cohort study. Datawere obtained from the PHARMO Record Linkage System; the PHARMO database contains pharmacy dispensing records of 3 million patients in the Netherlands registered with community pharmacies, linked to hospitalisation records

1 November 2009

Risk of hip/femur fracture after stroke: a population-based case-control study

BACKGROUND AND PURPOSE: Stroke increases the risk of hip/femur fracture, as seen in several studies, although the time course of this increased risk remains unclear. Therefore, our purpose is to evaluate this risk and investigate the time course ofany elevated risk. METHODS: We conducted a case-control study using the Dutch PHARMO Record Linkage System database

1 October 2009

Withdrawal of statins and risk of subarachnoid hemorrhage

BACKGROUND AND PURPOSE: Vascular endothelium, which can be affected by statins, is believed to play a substantial role in subarachnoid hemorrhage (SAH). Our objective was to estimate the association between use and withdrawal of statins and the risof SAH. METHODS: We conducted a population-based case-control study within the PHARMO database

1 August 2009

The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs

OBJECTIVE: To simultaneously assess cardiovascular (CV) and gastrointestinal (GI) risk with traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and cyclo-oxygenase 2 (COX-2) inhibitors. METHODS: Using the PHARMO Record Linkage System, incluing drug-dispensing and hospitalisation data of >2 million residents of The Netherlands, subjects with first hospitalisation for acute myocardial infarction (AMI), CV and GI events were identified

1 May 2009

Recruitment of participants through community pharmacies for a pharmacogenetic study of antihypertensive drug treatment

OBJECTIVE: To describe the design, recruitment and baseline characteristics of participants in a community pharmacy based pharmacogenetic study of antihypertensive drug treatment. SETTING: Participants enrolled from the population-based Pharmaco-Mobidity Record Linkage System. METHOD: We designed a nested case-control study in which we will assess whether specific genetic polymorphisms modify the effect of antihypertensive drugs on the risk of myocardial infarction

1 April 2009

Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction

INTRODUCTION: The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension. OBJECTIVE: The aim of the study was to determine whether the alpha-adducin 460Trp variant allelemodifies the risk-lowering effect of diuretics on myocardial infarction (MI)

1 January 2009

Psoriasis may not be an independent predictor for the use of cardiovascular and anti-diabetic drugs: a 5-year prevalence study

Most studies investigating the association between psoriasis and cardiovascular disease have shown a significant relationship. This comparison study investigated the association between psoriasis and prevalent use of cardiovascular drugs. Drug expoure data for 1998 to 2006 were extracted from the Dutch PHARMO-Record Linkage System database

1 January 2009

Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant

INTRODUCTION: The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI). Therefore, we assessed whether the effectiveness of statins in reducing the risk of MI wamodified by the GNB3 C825T polymorphism. METHODS: In a population-based registry of pharmacy records linked to hospital discharge records (PHARMO), we used a nested case-control design

1 July 2008