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Respiratory diseases Publications

Respiratory diseases Publications

  • Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction.Abstract

    BACKGROUND: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein. OBJECTIVES: To examine the association between the use of inhaled corticosteroidsand the risk of non-fatal acute MI. METHODS: In the Dutch PHARMO record linkage system database, we conducted a case-control study (2476 MI cases), nested in a cohort of antihypertensive drug users

    de Vries F, Pouwels S, Bracke M, Lammers JW, Leufkens H, Klungel O, van Staa T. J Hypertens. 2008 Jan; 26 (1): 124-129.
  • Enhanced persistence with tiotropium compared with other respiratory drugs in COPD.Abstract

    BACKGROUND: Tiotropium is a once-daily inhaled anticholinergic maintenance treatment with demonstrated effectiveness in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To compare persistence of tiotropium-use with other inhaled respiratorydrugs in COPD in current clinical practice. METHODS: The PHARMO database includes, among others, drug-dispensing and hospital discharge records for 2 million subjects in the Netherlands

    Breekveldt-Postma NS, Koerselman J, Erkens JA, Lammers JW, Herings RM. Respir Med. 2007 Jul; 101 (7): 1398-405.
  • Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study.Abstract

    INTRODUCTION: Administration of beta-2 agonists decreased bone mineral density in rats. But the association between bronchodilators and fracture risk has not been studied in humans. OBJECTIVES: To examine the association between use of beta-2 agonits and risk of hip/femur fracture. METHODS: We conducted a population-based case-control study (6763 cases) in the Dutch PHARMO database

    de Vries F, Pouwels S, Bracke M, Leufkens HG, Cooper C, Lammers JW, van Staa TP. Pharmacoepidemiol Drug Saf. 2007 Jun; 16 (6): 612-9.
  • Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence.Abstract

    BACKGROUND: In order to accurately distinguish gaps of varying length in drug treatment for chronic conditions from discontinuation without resuming therapy, short-term observation does not suffice. Thus, the use of inhalation corticosteroids (ICS)in the long-term, during a ten-year period is investigated

    Menckeberg TT, Belitser SV, Bouvy ML, Bracke M, Lammers JW, Raaijmakers JA, Leufkens HG. BMC Health Serv Res. 2007 7 106.
  • Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population.Abstract

    The aim of the present study was to assess whether the use of angiotensin-converting enzyme (ACE) inhibitors is associated with a decreased risk of hospitalisation for community-acquired pneumonia (CAP) in a general, essentially white population. Dta were obtained from the Dutch PHARMO Record Linkage System

    van deGarde EM, Souverein PC, van den Bosch JM, Deneer VH, Leufkens HG. Eur Respir J. 2006 Jun; 27 (6): 1217-22.