CNS disease Publications

• All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture.Abstract

  In the first year, after an osteoporotic fracture of a hip, forearm, upper arm, or spine, the dispensing rates of antidepressants and benzodiazepines increased significantly. After those fractures, recent and past use of antidepressants and benzodizepines was associated with increased all-cause mortality; current use was not associated with mortality risk

  deBruin IJA, Klop C, Wyers CE, Overbeek JA, Geusens Ppmm, van den Bergh JPW, Driessen JHM, deVries F. Osteoporos Int. 2019 Feb 8; 30 573-581.

• Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands.Abstract

  This is the first study to examine the association between antidepressant and benzodiazepine use following a MOF and risk of subsequent fracture in those 65+. Using national data, drug use following MOF showed that the 1-year fully adjusted risk ofsubsequent MOF in those on antidepressants was more than doubled

  van deVen LI, Klop C, Overbeek JA, deVries F, Burden AM, Janssen PK. Osteoporos Int. 2018 Aug 15; 29 2477-2485.