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Cardiovascular diseases Publications

Cardiovascular diseases Publications

  • Use of beta2 agonists and risk of acute myocardial infarction in patients with hypertension.Abstract

    WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Use of beta(2) agonists has been associated with tachycardia, an abnormal ECG and atrial fibrillation. * Previous observational studies of the association between use of beta(2) agonists and the risk of aute myocardial infarction (MI) have demonstrated conflicting results

    de Vries F, Pouwels S, Bracke M, Lammers JW, Klungel O, Leufkens H, van Staa T. Br J Clin Pharmacol. 2008 Apr; 65 (4): 580-6.
  • Effect of persistent use of antihypertensives on blood pressure goal attainment.Abstract

    OBJECTIVE: Discontinuation rates with antihypertensive drugs in real life are high. The present study investigates the relationship between persistence with antihypertensive drugs (AHT) and blood pressure (BP) goal attainment in daily clinical pracice. METHODS: In the PHARMO Record Linkage System, which includes drug dispensing and hospital records for > 2 million inhabitants in the Netherlands, new users of AHT > or = 18 years were identified for the period 1999-2004

    Breekveldt-Postma NS, Penning-van Beest FJ, Siiskonen SJ, Koerselman J, Klungel OH, Falvey H, Vincze G, Herings RM. Curr Med Res Opin. 2008 Apr; 24 (4): 1025-1031.
  • Risk of major bleeding during concomitant use of antibiotic drugs and coumarin anticoagulants.Abstract

    Background: Coumarin anticoagulants are prone to drug-drug interactions. For example, antibiotic drugs may enhance the anticoagulant effect of coumarins. However, whether such interactions are associated with an increased risk of bleeding, and if s, how frequently this occurs remains unknown. Objective: To assess the risk of major bleeding associated with the concomitant use of antibiotic drugs and coumarin anticoagulant therapy

    Penning-van Beest FJ, Koerselman J, Herings RM. J Thromb Haemost. 2008 Feb; 6 (2): 284-90.
  • A cross-national study of the persistence of antihypertensive medication use in the elderly.Abstract

    INTRODUCTION: Little is known about cross-national comparisons of the persistence of antihypertensive medication treatment, trends in persistence, and factors associated with persistence. The aim of this study was to describe and compare patterns ouse of antihypertensive drugs in a population of elderly patients in the United States (Pennsylvania), Canada (British Columbia) and the Netherlands

    van Wijk BL, Shrank WH, Klungel OH, Schneeweiss S, Brookhart MA, Avorn J. J Hypertens. 2008 Jan; 26 (1): 145-153.
  • The effect of discontinuation of antihypertensives on the risk of acute myocardial infarction and stroke.Abstract

    OBJECTIVE: Adherence to antihypertensive drug treatment is suboptimal. The present study investigates the effect of early treatment discontinuation with antihypertensive drugs on the risk of acute myocardial infarction (AMI) or stroke in daily clincal practice. METHODS: In the PHARMO Record Linkage System, which includes all records of drug dispensings and hospitalisations for > or = 2 million subjects in the Netherlands, new users of antihypertensive (AHT) drugs > or = 18 years of age were studied during the period 1 January 1993 – 1 October 2002 to determine the risk of AMI or stroke related to persistence with AHT

    Breekveldt-Postma NS, Penning-van Beest FJ, Siiskonen SJ, Falvey H, Vincze G, Klungel OH, Herings RM. Curr Med Res Opin. 2008 Jan; 24 (1): 121-7.
  • Incidence of cardiovascular events in breast cancer patients receiving chemotherapy in clinical practice.Abstract

    PURPOSE: To assess the incidence of cardiovascular events among breast cancer patients after chemotherapy. METHODS: Women >/=18 years with a breast tumour who received chemotherapy in 1992-2003 were selected from the PHARMO RLS. Chemotherapy with athracyclines, a combination of anthracyclines and taxanes or second line treatment with trastuzumab was classified as cardiotoxic

    Sukel MP, Breekveldt-Postma NS, Erkens JA, van der Linden PD, Beider beck AB, Coebergh JW, Herings RM. Pharmacoepidemiol Drug Saf. 2008 Jan; 17 (2): 125-134.
  • Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction.Abstract

    BACKGROUND: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein. OBJECTIVES: To examine the association between the use of inhaled corticosteroidsand the risk of non-fatal acute MI. METHODS: In the Dutch PHARMO record linkage system database, we conducted a case-control study (2476 MI cases), nested in a cohort of antihypertensive drug users

    de Vries F, Pouwels S, Bracke M, Lammers JW, Leufkens H, Klungel O, van Staa T. J Hypertens. 2008 Jan; 26 (1): 124-129.
  • Quantity and quality of potential drug interactions with coumarin anticoagulants in the Netherlands.Abstract

    OBJECTIVE: Coumarin anticoagulants are prone to potentially life-threatening drug-drug interactions due to a combination of unfavorable properties. However, real life data on the actual occurrence are scarce. The aim of this study was to quantify ad qualify potential drug interactions with coumarin anticoagulants in daily practice

    Penning-van Beest FJ, Koerselman J, Herings RM. Pharm World Sci. 2007 Dec; 29 (6): 671-5.
  • Is statin use associated with a reduced incidence, a reduced Breslow thickness or delayed metastasis of melanoma of the skin?.Abstract

    BACKGROUND: Statins show anticancer activity in melanoma cells. We investigated the association between statins and incidence and Breslow thickness of cutaneous melanoma (CM). METHODS: Data were used from PHARMO, a pharmacy database, and PALGA, a pthological database, in the Netherlands. Cases had a primary CM diagnosis between January 1st 1991 and December 14th 2004, were 18 years and had 3 years of follow up in PHARMO before CM diagnosis

    Koomen ER, Joosse A, Herings RM, Casparie MK, Bergman W, Nijsten T, Guchelaar HJ. Eur J Cancer. 2007 Nov; 43 (17): 2580-9.
  • Effect of drug combinations on admission for recurrent myocardial infarction.Abstract

    OBJECTIVE: To determine the effect of the number of different drugs with adherence to medication of at least 70% on recurrent admission for myocardial infarction (MI) in patients with a history of MI. DESIGN: Nested case-control study in a dynamicohort. SETTING: PHARMO database that contains pharmacy dispensing records and hospital discharge records of 350,000 Dutch citizens

    van der Elst ME, Bouvy ML, deBlaey CJ, deBoer A. Heart. 2007 Oct; 93 (10): 1226-30.