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Cardiovascular diseases Publications

Cardiovascular diseases Publications

  • Comparison of incidences of cardiovascular events among new users of different statins: a retrospective observational cohort study.Abstract

    OBJECTIVE: To compare incidences of cardiovascular disease (CVD) in general and myocardial infarction (MI) specifically between new users of different statins in daily practice. DESIGN AND METHODOLOGY: Retrospective observational cohort study. Datawere obtained from the PHARMO Record Linkage System; the PHARMO database contains pharmacy dispensing records of 3 million patients in the Netherlands registered with community pharmacies, linked to hospitalisation records

    Heintjes EM, Penning-van Beest FJ, Johansson S, Stalenhoef AF, Herings RM. Curr Med Res Opin. 2009 Nov; 25 (11): 2621-9.
  • Melanoma incidence and exposure to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.Abstract

    A reduced incidence of nonmelanoma skin cancer among users of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARb) has been reported. A similar effect is suggested for cutaneous melanoma. We aimed to investigate te possible association between use of ACEi and ARb and the risk of cutaneous melanoma

    Koomen ER, Herings RM, Guchelaar HJ, Nijsten T. Cancer Epidemiol. 2009 Nov; 33 (5): 391-5.
  • Risk of hip/femur fracture after stroke: a population-based case-control study.Abstract

    BACKGROUND AND PURPOSE: Stroke increases the risk of hip/femur fracture, as seen in several studies, although the time course of this increased risk remains unclear. Therefore, our purpose is to evaluate this risk and investigate the time course ofany elevated risk. METHODS: We conducted a case-control study using the Dutch PHARMO Record Linkage System database

    Pouwels S, Lalmohamed A, Leufkens B, de Boer A, Cooper C, van Staa T, de Vries F. Stroke. 2009 Oct; 40 (10): 3281-5.
  • Withdrawal of statins and risk of subarachnoid hemorrhage.Abstract

    BACKGROUND AND PURPOSE: Vascular endothelium, which can be affected by statins, is believed to play a substantial role in subarachnoid hemorrhage (SAH). Our objective was to estimate the association between use and withdrawal of statins and the risof SAH. METHODS: We conducted a population-based case-control study within the PHARMO database

    Risselada R, Straatman H, van Kooten F, Dippel DW, van der Lugt A, Niessen WJ, Firouzian A, Herings RM, Sturkenboom MC. Stroke. 2009 Aug; 40 (8): 2887-92.
  • The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs.Abstract

    OBJECTIVE: To simultaneously assess cardiovascular (CV) and gastrointestinal (GI) risk with traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and cyclo-oxygenase 2 (COX-2) inhibitors. METHODS: Using the PHARMO Record Linkage System, incluing drug-dispensing and hospitalisation data of >2 million residents of The Netherlands, subjects with first hospitalisation for acute myocardial infarction (AMI), CV and GI events were identified

    van der Linden MW, van der Bij S, Welsing P, Kuipers EJ, Herings RM. Ann Rheum Dis. 2009 May; 68 (5): 668-73.
  • Recruitment of participants through community pharmacies for a pharmacogenetic study of antihypertensive drug treatment.Abstract

    OBJECTIVE: To describe the design, recruitment and baseline characteristics of participants in a community pharmacy based pharmacogenetic study of antihypertensive drug treatment. SETTING: Participants enrolled from the population-based Pharmaco-Mobidity Record Linkage System. METHOD: We designed a nested case-control study in which we will assess whether specific genetic polymorphisms modify the effect of antihypertensive drugs on the risk of myocardial infarction

    van Wieren-deWijer DB, Maitland-van der Zee AH, deBoer A, Stricker BH, Kroon AA, deLeeuw PW, Bozkurt O, Klungel OH. Pharm World Sci. 2009 Apr; 31 (2): 158-64.
  • Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction.Abstract

    INTRODUCTION: The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension. OBJECTIVE: The aim of the study was to determine whether the alpha-adducin 460Trp variant allelemodifies the risk-lowering effect of diuretics on myocardial infarction (MI)

    van Wieren-deWijer DB, Maitland-van der Zee AH, deBoer A, Kroon AA, deLeeuw PW, Schiffers P, Janssen RG, Psaty BM, van Duijn CM, Stricker BH, Klungel OH. J Hypertens. 2009 Jan; 27 (1): 61-8.
  • Psoriasis may not be an independent predictor for the use of cardiovascular and anti-diabetic drugs: a 5-year prevalence study.Abstract

    Most studies investigating the association between psoriasis and cardiovascular disease have shown a significant relationship. This comparison study investigated the association between psoriasis and prevalent use of cardiovascular drugs. Drug expoure data for 1998 to 2006 were extracted from the Dutch PHARMO-Record Linkage System database

    Wakkee M, Meijer W, Neumann HA, Herings RM, Nijsten T. Acta Derm Venereol. 2009 89 (5): 476-83.
  • Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant.Abstract

    INTRODUCTION: The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI). Therefore, we assessed whether the effectiveness of statins in reducing the risk of MI wamodified by the GNB3 C825T polymorphism. METHODS: In a population-based registry of pharmacy records linked to hospital discharge records (PHARMO), we used a nested case-control design

    Peters BJ, Maitland-van der Zee AH, Stricker BH, van Wieren-deWijer DB, deBoer A, Kroon AA, deLeeuw PW, Schiffers P, Janssen RG, van Duijn CM, Klungel OH. Pharmacogenet Genomics. 2008 Jul; 18 (7): 631-6.
  • LDL-C reductions and goal attainment among naive statin users in the Netherlands: real life results.Abstract

    OBJECTIVE: The effectiveness of statin therapy in a real life setting may differ from that in clinical trials, as physicians make non-randomised treatment decisions for patients with less uniform and possibly different characteristics. We thereforeperformed a study to compare the effectiveness of different statins and doses in routine clinical practice with respect to total serum cholesterol and LDL-cholesterol (LDL-C) reduction and goal attainment according to European guidelines on the prevention of cardiovascular disease (CVD)

    Heintjes EM, Hirsch MW, Vander Linden MW, O'Donnell JC, Stalenhoef AF, Herings RMC. Curr Med Res Opin. 2008 June 24, 2; 24 (8): 2241-2250.