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Cardiovascular diseases Publications

Cardiovascular diseases Publications

  • Platelet aggregation inhibitors, vitamin K antagonists and risk of subarachnoid hemorrhage.Abstract

    BACKGROUND: Use of platelet aggregation inhibitors and vitamin K antagonists has been associated with an increased risk of intracranial hemorrhage (ICH). Whether the use of these antithrombotic drugs is associated with an increased risk of subarachoid hemorrhage (SAH) remains unclear, especially as confounding by indication might play a role

    Risselada R, Straatman H, van Kooten F, Dippel DW, van der Lugt A, Niessen WJ, Firouzian A, Herings RM, Sturkenboom MC. J Thromb Haemost. 2011 Mar; 9 (3): 517-23.
  • Non-selective vs. selective beta-blocker treatment and the risk of thrombo-embolic events in patients with heart failure.Abstract

    AIMS: Heart failure (HF) is associated with a prothrombotic state, resulting in an increased risk for thrombo-embolic events. Studies suggest a reduced prothrombotic state when non-selective beta-blockers relative to selective beta-blockers are givn. We studied the influence of non-selective beta-blockers compared with selective beta-blockers on the occurrence of arterial and venous thrombo-embolic events in patients with HF

    de Peuter OR, Souverein PC, Klungel OH, Buller HR, de Boer A, Kamphuisen PW. Eur J Heart Fail. 2011 Feb; 13 (2): 220-6.
  • Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors.Abstract

    BACKGROUND: The association between myocardial infarction (MI) and co-administration of proton pump inhibitors (PPIs) and clopidogrel remains controversial. AIM: To quantify the association between concomitant use of PPIs and clopidogrel and occurrnce of recurrent MI. METHODS: We conducted a case-control study within a cohort of acute MI patients in PHARMO Record Linkage System (1999-2008)

    Valkhoff VE, tJong GW, VanSoest EM, Kuipers EJ, Sturkenboom MC. Aliment Pharmacol Ther. 2011 Jan; 33 (1): 77-88.
  • Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction.Abstract

    OBJECTIVE: To investigate the influence of tagging single-nucleotide polymorphisms (SNPs) within candidate genes involved in the putative anti-inflammatory effects of statins on the effectiveness of statins in reducing the risk of myocardial infarcion (MI). METHODS: We conducted a case-control study in a population-based registry of pharmacy records linked to hospital discharge records (PHARMO)

    Peters BJ, Rodin AS, Klungel OH, Stricker BH, deBoer A, Maitland-van der Zee AH. Pharmacogenet Genomics. 2010 Dec; 20 (12): 766-74.
  • Use of multiple international healthcare databases for the detection of rare drug-associated outcomes: a pharmacoepidemiological programme comparing rosuvastatin with other marketed statins.Abstract

    BACKGROUND: Statins (inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA reductase) are associated with rare but serious adverse events involving the muscle, kidney and liver. To compare the safety profile of rosuvastatin with other marketed statins, foupharmacoepidemiological studies were conducted using different national healthcare databases

    Garcia Rodriguez LA, Herings R, Johansson S. Pharmacoepidemiol Drug Saf. 2010 Dec; 19 (12): 1218-24.
  • Characteristics and drug utilization patterns of new users of rosuvastatin and other statins in four countries.Abstract

    AIM: This study was undertaken to increase understanding of the utilization of a newly introduced statin through evaluation of characteristics of ‘real-life’ patients in a pharmacoepidemiology program in the USA, the Netherlands, the UK and Canada.METHODS: This was an observational analysis of prospectively collected data from primary care patients classified as new users of rosuvastatin or any other statin

    McAfee AT, Rodriguez LA, Goettsch WG, Gonzalez-Perez A, Johansson S, Ming EE, Wallander MA, Herings RM. Minerva Cardioangiol. 2010 Dec; 58 (6): 611-22.
  • Antipsychotic drug use and the risk of venous thromboembolism in elderly patients.Abstract

    OBJECTIVE: Our aim was to investigate the relationship between exposure to antipsychotic drugs and the risk of venous thromboembolism (VTE) in elderly patients. METHODS: A time-matched case-control analysis nested within a cohort of 111,818 patientwith at least 1 antipsychotic drug prescription during 1998 to 2008

    Kleijer BC, Heerdink ER, Egberts TC, Jansen PA, van Marum RJ. J Clin Psychopharmacol. 2010 Oct; 30 (5): 526-30.
  • Psoriasis may not be an independent risk factor for acute ischemic heart disease hospitalizations: results of a large population-based Dutch cohort.Abstract

    Although psoriasis has been associated with components of the metabolic syndrome, its association with myocardial infarction is less clear. A cohort study was conducted using hospital and pharmacy records of 2.5 million Dutch residents between 1997and 2008. The risk of ischemic heart disease (IHD) hospitalizations was compared between psoriasis patients and a matched reference cohort

    Wakkee M, Herings RM, Nijsten T. J Invest Dermatol. 2010 Apr; 130 (4): 962-7.
  • Use of organic nitrates and the risk of hip fracture: a population-based case-control study.Abstract

    CONTEXT: Use of organic nitrates has been associated with increased bone mineral density. Moreover, a large Danish case-control study reported a decreased fracture risk. However, the association with duration of nitrate use, dose frequency, and impct of discontinuation has not been extensively studied

    Pouwels S, Lalmohamed A, van Staa T, Cooper C, Souverein P, Leufkens HG, Rejnmark L, de Boer A, Vestergaard P, de Vries F. J Clin Endocrinol Metab. 2010 Apr; 95 (4): 1924-31.
  • Determination of non-treatment with statins of high risk patients in The Netherlands.Abstract

    OBJECTIVE: To determine in the Netherlands what proportions of high risk patients with established cardiovascular disease (CVD) or diabetes mellitus type 2 (DM2) who were not treated with statins on 1 January 2007 and which characteristics were assciated with non-treatment. METHODS: From the IPCI GP database patients were selected who were registered with a GP on 1 January 2007 who had a history of either CVD (CVD patients), DM2 (diabetics) or both (diabetics with CVD)

    van den Haak P, Heintjes E, Plat AW, JanMeerding W, Webb K, Sturkenboom MC, Herings RM. Curr Med Res Opin. 2010 Feb; 26 (2): 271-8.