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Drug utilization study Publications

Drug utilization study Publications

  • Treatment with inhaled corticosteroids in asthma is too often discontinued.Abstract

    PURPOSE: To study persistence with inhaled corticosteroids (ICS) and its determinants in asthma-patients. METHODS: From the PHARMO database, asthma-patients (age < 35 years) with a first dispensing for ICS in 1999-2002 and >/= 2 dispensings in theirst year were included. Persistence during the first year was defined as the number of days from start to time of first failure to continue renewal of the initial ICS

    Breekveldt-Postma NS, Koerselman J, Erkens JA, van der Molen T, Lammers JW, Herings RM. Pharmacoepidemiol Drug Saf. 2008 Apr; 17 (4): 411-422.
  • Large-scale stopping and switching treatment with COX-2 inhibitors after the rofecoxib withdrawal.Abstract

    PURPOSE: To compare treatment changes after the rofecoxib withdrawal with changes occurring normally and to re-assess 12 months afterwards. METHODS: The PHARMO database comprised medication and hospital discharge records of over 3 million inhabitans in the Netherlands. The Study cohort included chronic coxib users with a coxib prescription on 30th September 2004; the Reference cohort others with a coxib prescription on 1st June 2004

    Sukel MP, van der Linden MW, Chen C, Erkens JA, Herings RM. Pharmacoepidemiol Drug Saf. 2008 Jan; 17 (1): 9-19.
  • A cross-national study of the persistence of antihypertensive medication use in the elderly.Abstract

    INTRODUCTION: Little is known about cross-national comparisons of the persistence of antihypertensive medication treatment, trends in persistence, and factors associated with persistence. The aim of this study was to describe and compare patterns ouse of antihypertensive drugs in a population of elderly patients in the United States (Pennsylvania), Canada (British Columbia) and the Netherlands

    van Wijk BL, Shrank WH, Klungel OH, Schneeweiss S, Brookhart MA, Avorn J. J Hypertens. 2008 Jan; 26 (1): 145-153.
  • Enhanced persistence with tiotropium compared with other respiratory drugs in COPD.Abstract

    BACKGROUND: Tiotropium is a once-daily inhaled anticholinergic maintenance treatment with demonstrated effectiveness in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To compare persistence of tiotropium-use with other inhaled respiratorydrugs in COPD in current clinical practice. METHODS: The PHARMO database includes, among others, drug-dispensing and hospital discharge records for 2 million subjects in the Netherlands

    Breekveldt-Postma NS, Koerselman J, Erkens JA, Lammers JW, Herings RM. Respir Med. 2007 Jul; 101 (7): 1398-405.
  • Rates and determinants of reinitiating antihypertensive therapy after prolonged stoppage: a population-based study.Abstract

    OBJECTIVE: To assess patterns of restarting antihypertensive drugs after a prolonged period of discontinuation. METHODS: We conducted a retrospective cohort study among new users of blood pressure-lowering medication in the PHARMO database in the Ntherlands, who had a period of at least 180 days without such medication

    van Wijk BL, Avorn J, Solomon DH, Klungel OH, Heerdink ER, de Boer A, Brookhart AM. J Hypertens. 2007 Mar; 25 (3): 689-697.
  • Higher persistence with valsartan compared with enalapril in daily practice.Abstract

    OBJECTIVE: To compare persistence with valsartan and enalapril in daily practice. METHODS: The PHARMO Record Linkage System includes various data registries including drug dispensing and hospitalizations for > or =2 million subjects in the Netherlads. Patients newly treated with valsartan or enalapril in the period of 1999-2002 were selected

    Siiskonen SJ, Breekveldt-Postma NS, Vincze G, Khan ZM, Erkens JA, Herings RM. Vasc Health Risk Manag. 2007 3 (6): 1039-44.
  • Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy.Abstract

    PURPOSE: Discontinuation with treatment is a major problem in the treatment of hypertension. The objective of our study was to assess the association between non-compliance and discontinuation in patients who started using antihypertensive monotherpy. METHODS: A nested case-control study within a cohort of new users of antihypertensive drugs between 1st January 1999 and 31st December 2002 was performed

    VanWijk BL, Klungel OH, Heerdink ER, de Boer A. Pharmacoepidemiol Drug Saf. 2006 Apr 3; 15 (8): 587-93.
  • Determinants of persistence with bisphosphonates: a study in women with postmenopausal osteoporosis.Abstract

    BACKGROUND: Although bisphosphonates are useful in the management of osteoporosis, patients often discontinue treatment. OBJECTIVES: The aims of this study were to investigate persistence with bisphosphonates, and to assess whether the dose intervainfluenced persistence, among women with postmenopausal osteoporosis

    Penning-van Beest FJ, Goettsch WG, Erkens JA, Herings RM. Clin Ther. 2006 Feb; 28 (2): 236-42.
  • Generic substitution of antihypertensive drugs: does it affect adherence?.Abstract

    BACKGROUND: Generic substitution is an important opportunity to reduce the costs of pharmaceutical care. However, pharmacists and physicians often find that patients and brand-name manufacturers have doubt about the equivalence of the substituted dug. This may be reflected by decreased adherence to therapy

    VanWijk BL, Klungel OH, Heerdink ER, de Boer A. Ann Pharmacother. 2006 Jan; 40 (1): 15-20.