Archives

• Treatment with inhaled corticosteroids in asthma is too often discontinued

  PURPOSE: To study persistence with inhaled corticosteroids (ICS) and its determinants in asthma-patients. METHODS: From the PHARMO database, asthma-patients (age < 35 years) with a first dispensing for ICS in 1999-2002 and >/= 2 dispensings in theirs...

• A cross-national study of the persistence of antihypertensive medication use in the elderly

  INTRODUCTION: Little is known about cross-national comparisons of the persistence of antihypertensive medication treatment, trends in persistence, and factors associated with persistence. The aim of this study was to describe and compare patterns ous...

• Large-scale stopping and switching treatment with COX-2 inhibitors after the rofecoxib withdrawal

  PURPOSE: To compare treatment changes after the rofecoxib withdrawal with changes occurring normally and to re-assess 12 months afterwards. METHODS: The PHARMO database comprised medication and hospital discharge records of over 3 million inhabitans ...

• Enhanced persistence with tiotropium compared with other respiratory drugs in COPD

  BACKGROUND: Tiotropium is a once-daily inhaled anticholinergic maintenance treatment with demonstrated effectiveness in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To compare persistence of tiotropium-use with other inhaled respiratorydr...

• Rates and determinants of reinitiating antihypertensive therapy after prolonged stoppage: a population-based study

  OBJECTIVE: To assess patterns of restarting antihypertensive drugs after a prolonged period of discontinuation. METHODS: We conducted a retrospective cohort study among new users of blood pressure-lowering medication in the PHARMO database in the Nth...

• Higher persistence with valsartan compared with enalapril in daily practice

  OBJECTIVE: To compare persistence with valsartan and enalapril in daily practice. METHODS: The PHARMO Record Linkage System includes various data registries including drug dispensing and hospitalizations for > or =2 million subjects in the Netherlads...

• Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy

  PURPOSE: Discontinuation with treatment is a major problem in the treatment of hypertension. The objective of our study was to assess the association between non-compliance and discontinuation in patients who started using antihypertensive monotherpy...

• Determinants of persistence with bisphosphonates: a study in women with postmenopausal osteoporosis

  BACKGROUND: Although bisphosphonates are useful in the management of osteoporosis, patients often discontinue treatment. OBJECTIVES: The aims of this study were to investigate persistence with bisphosphonates, and to assess whether the dose intervain...

• Generic substitution of antihypertensive drugs: does it affect adherence?

  BACKGROUND: Generic substitution is an important opportunity to reduce the costs of pharmaceutical care. However, pharmacists and physicians often find that patients and brand-name manufacturers have doubt about the equivalence of the substituted dug...