Archives

• Antibiotic prescribing on admission to patients with pneumonia and prior outpatient antibiotic treatment: a cohort study on clinical outcome

  OBJECTIVE: Most pneumonia treatment guidelines recommend that prior outpatient antibiotic treatment should be considered when planning inpatient antibiotic regimen. Our purpose was to study in patients admitted for community-acquired pneumonia theode...

• Population-based cohort study of anti-infective medication use before and after the onset of type 1 diabetes in children and adolescents

  A population-based cohort study was conducted in the Dutch PHARMO database to investigate prevalence and patterns of anti-infective medication use in children and adolescents with type 1 diabetes (T1D) before and after the onset of this disease. Alpa...

• Isotretinoin exposure during pregnancy: a population-based study in The Netherlands

  OBJECTIVE: To estimate isotretinoin exposure in Dutch pregnant women despite the implemented pregnancy prevention programme (PPP) and second, to analyse the occurrence of adverse fetal or neonatal outcomes in these isotretinoin exposed pregnancies.DE...

• Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study

  BACKGROUND: To describe the utilisation of antibiotics in children and adolescents across 5 European countries based on the same drug utilisation measures and age groups. Special attention was given to age-group-specific distributions of antibioticsu...

• Persisting gender differences and attenuating age differences in cardiovascular drug use for prevention and treatment of coronary heart disease, 1998-2010

  BACKGROUND: Evidence on recent time trends in age-gender differences in cardiovascular drug use is scarce. We studied time trends in age-gender-specific cardiovascular drug use for primary prevention, secondary prevention, and in-hospital treatmentof...

• Increased Antidepressant Drug Exposure in Psoriasis Patients: A Longitudinal Population-based Cohort Study

  Psoriasis has a major impact on health-related quality of life. The present cohort study investigated the use of antidepressant drugs in psoriasis patients and a reference cohort, using pharmacy and hospitalization data from 1998 to 2008 for more tan...

• Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy

  BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) and sublingual allergen immunotherapy (SLIT) are safe and effective treatments of allergic rhinitis, but high levels of compliance and persistence are crucial to achieving the desired clinicalffe...

• Major changes in chemotherapy regimens administered to breast cancer patients during 2000-2008 in the Netherlands

  There is little information available on the patterns of chemotherapy regimens administered in daily practice to patients with early stage and metastatic or recurrent breast cancer. To determine the trends in type of chemotherapy regimens used in bea...

• First year of life medication use and hospital admission rates: premature compared with term infants

  OBJECTIVE: To compare hospitalization and medication use during the first year of life in preterm-born and term-born infants. STUDY DESIGN: Data for this retrospective cohort study were obtained from the linked PHARMO-Netherlands Perinatal Registryco...

• Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen

  Tamoxifen is a largely inactive pro-drug, requiring metabolism into its most important metabolite endoxifen. Since the cytochrome P450 (CYP) 2D6 enzyme is primarily involved in this metabolism, genetic polymorphisms of this enzyme, but also drug-inuc...