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Drug safety study Publications

Drug safety study Publications

  • The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs.Abstract

    OBJECTIVE: To simultaneously assess cardiovascular (CV) and gastrointestinal (GI) risk with traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and cyclo-oxygenase 2 (COX-2) inhibitors. METHODS: Using the PHARMO Record Linkage System, incluing drug-dispensing and hospitalisation data of >2 million residents of The Netherlands, subjects with first hospitalisation for acute myocardial infarction (AMI), CV and GI events were identified

    van der Linden MW, van der Bij S, Welsing P, Kuipers EJ, Herings RM. Ann Rheum Dis. 2009 May; 68 (5): 668-73.
  • Estrogens, oral contraceptives and hormonal replacement therapy increase the incidence of cutaneous melanoma: a population-based case-control study.Abstract

    BACKGROUND: Multiple studies showed conflicting results on the association between oral contraceptive (OC) use and the development of cutaneous melanoma (CM). We investigated the association between estrogen use and CM incidence. PATIENTS AND METHOS: Data from PHARMO Pharmacy database and PALGA, the pathology database in The Netherlands, were linked

    Koomen ER, Joosse A, Herings RM, Casparie MK, Guchelaar HJ, Nijsten T. Ann Oncol. 2009 Feb; 20 (2): 358-64.
  • Topical corticosteroids and the risk of diabetes mellitus: a nested case-control study in the Netherlands.Abstract

    The relationship between topical corticosteroid use, potency, treatment duration, concomitant exposure to systemic corticosteroids, and risk of diabetes has been incompletely studied. To investigate an association between intense, longstanding topial corticosteroid use and diabetes mellitus. Data for this nested case-control study were obtained from the PHARMO Record Linkage System, including linked drug dispensing and hospital records of >2

    van der Linden MW, Penning-van Beest FJ, Nijsten T, Herings RM. Drug Saf. 2009 32 (6): 527-37.
  • Influence of antidepressants on glycaemic control in patients with diabetes mellitus.Abstract

    PURPOSE: Anecdotal evidence suggests that antidepressants (ADs) may complicate glycaemic control. The objective of this longitudinal study was to investigate the influence of ADs on glycaemic control within diabetes patients. METHODS: From the pharacy registry database PHARMO, we selected insulin users who did not use oral antidiabetics

    Knol MJ, Derijks HJ, Geerlings MI, Heerdink ER, Souverein PC, Gorter KJ, Grobbee DE, Egberts AC. Pharmacoepidemiol Drug Saf. 2008 Jun; 17 (6): 577-86.
  • Use of beta2 agonists and risk of acute myocardial infarction in patients with hypertension.Abstract

    WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Use of beta(2) agonists has been associated with tachycardia, an abnormal ECG and atrial fibrillation. * Previous observational studies of the association between use of beta(2) agonists and the risk of aute myocardial infarction (MI) have demonstrated conflicting results

    de Vries F, Pouwels S, Bracke M, Lammers JW, Klungel O, Leufkens H, van Staa T. Br J Clin Pharmacol. 2008 Apr; 65 (4): 580-6.
  • Antipsychotic drug use and risk of pneumonia in elderly people.Abstract

    OBJECTIVES: To investigate the association between antipsychotic drug use and risk of pneumonia in elderly people. DESIGN: A nested case-control analysis. SETTING: Data were used from the PHARMO database, which collates information from community parmacies and hospital discharge records. PARTICIPANTS: A cohort of 22,944 elderly people with at least one antipsychotic prescription; 543 cases of hospital admission for pneumonia were identified

    Knol W, van Marum RJ, Jansen PA, Souverein PC, Schobben AF, Egberts AC. J Am Geriatr Soc. 2008 Apr; 56 (4): 661-6.
  • The association between antidepressant use and hypoglycaemia in diabetic patients: a nested case-control study.Abstract

    PURPOSE: Hypoglycaemia is a limiting factor for glycaemic management of diabetes with intensive insulin and/or oral antidiabetic drug (OAD) regimen. Case reports suggest that antidepressants may interfere with blood glucose metabolism in patients wth diabetes mellitus potentially increasing the risk of clinically relevant hypoglycaemia

    Derijks HJ, Heerdink ER, DeKoning FH, Janknegt R, Klungel OH, Egberts AC. Pharmacoepidemiol Drug Saf. 2008 Apr; 17 (4): 336-44.
  • Risk of major bleeding during concomitant use of antibiotic drugs and coumarin anticoagulants.Abstract

    Background: Coumarin anticoagulants are prone to drug-drug interactions. For example, antibiotic drugs may enhance the anticoagulant effect of coumarins. However, whether such interactions are associated with an increased risk of bleeding, and if s, how frequently this occurs remains unknown. Objective: To assess the risk of major bleeding associated with the concomitant use of antibiotic drugs and coumarin anticoagulant therapy

    Penning-van Beest FJ, Koerselman J, Herings RM. J Thromb Haemost. 2008 Feb; 6 (2): 284-90.
  • Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction.Abstract

    BACKGROUND: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein. OBJECTIVES: To examine the association between the use of inhaled corticosteroidsand the risk of non-fatal acute MI. METHODS: In the Dutch PHARMO record linkage system database, we conducted a case-control study (2476 MI cases), nested in a cohort of antihypertensive drug users

    de Vries F, Pouwels S, Bracke M, Lammers JW, Leufkens H, Klungel O, van Staa T. J Hypertens. 2008 Jan; 26 (1): 124-129.
  • Incidence of cardiovascular events in breast cancer patients receiving chemotherapy in clinical practice.Abstract

    PURPOSE: To assess the incidence of cardiovascular events among breast cancer patients after chemotherapy. METHODS: Women >/=18 years with a breast tumour who received chemotherapy in 1992-2003 were selected from the PHARMO RLS. Chemotherapy with athracyclines, a combination of anthracyclines and taxanes or second line treatment with trastuzumab was classified as cardiotoxic

    Sukel MP, Breekveldt-Postma NS, Erkens JA, van der Linden PD, Beider beck AB, Coebergh JW, Herings RM. Pharmacoepidemiol Drug Saf. 2008 Jan; 17 (2): 125-134.