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Drug effectiveness study Publications

Drug effectiveness study Publications

  • LDL-C reductions and goal attainment among naive statin users in the Netherlands: real life results.Abstract

    OBJECTIVE: The effectiveness of statin therapy in a real life setting may differ from that in clinical trials, as physicians make non-randomised treatment decisions for patients with less uniform and possibly different characteristics. We thereforeperformed a study to compare the effectiveness of different statins and doses in routine clinical practice with respect to total serum cholesterol and LDL-cholesterol (LDL-C) reduction and goal attainment according to European guidelines on the prevention of cardiovascular disease (CVD)

    Heintjes EM, Hirsch MW, Vander Linden MW, O'Donnell JC, Stalenhoef AF, Herings RMC. Curr Med Res Opin. 2008 June 24, 2; 24 (8): 2241-2250.
  • Loss of treatment benefit due to low compliance with bisphosphonate therapy.Abstract

    SUMMARY: Among 8,822 new female bisphosphonate users, non-compliant bisphosphonate use was associated with a 45% increased risk of osteoporotic fracture compared to compliant use (MPR >or=80%). Classifying compliance into five categories, fractureisk gradually increased with poorer compliance. These results emphasize the importance of treatment compliance in obtaining maximal treatment benefit

    Penning-van Beest FJ, Erkens JA, Olson M, Herings RM. Osteoporos Int. 2008 Apr; 19 (4): 511-7.
  • Effect of persistent use of antihypertensives on blood pressure goal attainment.Abstract

    OBJECTIVE: Discontinuation rates with antihypertensive drugs in real life are high. The present study investigates the relationship between persistence with antihypertensive drugs (AHT) and blood pressure (BP) goal attainment in daily clinical pracice. METHODS: In the PHARMO Record Linkage System, which includes drug dispensing and hospital records for > 2 million inhabitants in the Netherlands, new users of AHT > or = 18 years were identified for the period 1999-2004

    Breekveldt-Postma NS, Penning-van Beest FJ, Siiskonen SJ, Koerselman J, Klungel OH, Falvey H, Vincze G, Herings RM. Curr Med Res Opin. 2008 Apr; 24 (4): 1025-1031.
  • Haemoglobin A(1)(c) Goal Attainment in Relation to Dose in Patients with Diabetes Mellitus Taking Metformin : A Nested, Case-Control Study.Abstract

    BACKGROUND and objective: Conclusions from clinical trials suggest possible therapeutic advantages for once-daily agents over twice-daily agents in the treatment of type 2 diabetes mellitus. This study set out to investigate the relationship betweemetformin dosing frequency and glycosylated haemoglobin (HbA(1c))-goal attainment in daily practice

    Penning-van Beest FJ, Wolffenbuttel BH, Herings RM. Clin Drug Investig. 2008 28 (8): 487-493.
  • Relationship between duration of compliant bisphosphonate use and the risk of osteoporotic fractures.Abstract

    OBJECTIVES: To investigate the relationship between duration of compliant bisphosphonate use and the risk of osteoporotic fractures.METHODS: The PHARMO database was used to identify new female bisphosphonate users, aged >/= 45 years or with diagnosd post-menopausal osteoporosis in the period of January 1996 – June 2004

    Meijer WM, Beest FJ, Olson M, Herings RM. Curr Med Res Opin. 2008 Inpress; 24 (11): 3217-3222.
  • The effect of discontinuation of antihypertensives on the risk of acute myocardial infarction and stroke.Abstract

    OBJECTIVE: Adherence to antihypertensive drug treatment is suboptimal. The present study investigates the effect of early treatment discontinuation with antihypertensive drugs on the risk of acute myocardial infarction (AMI) or stroke in daily clincal practice. METHODS: In the PHARMO Record Linkage System, which includes all records of drug dispensings and hospitalisations for > or = 2 million subjects in the Netherlands, new users of antihypertensive (AHT) drugs > or = 18 years of age were studied during the period 1 January 1993 – 1 October 2002 to determine the risk of AMI or stroke related to persistence with AHT

    Breekveldt-Postma NS, Penning-van Beest FJ, Siiskonen SJ, Falvey H, Vincze G, Klungel OH, Herings RM. Curr Med Res Opin. 2008 Jan; 24 (1): 121-7.
  • Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction.Abstract

    BACKGROUND: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein. OBJECTIVES: To examine the association between the use of inhaled corticosteroidsand the risk of non-fatal acute MI. METHODS: In the Dutch PHARMO record linkage system database, we conducted a case-control study (2476 MI cases), nested in a cohort of antihypertensive drug users

    de Vries F, Pouwels S, Bracke M, Lammers JW, Leufkens H, Klungel O, van Staa T. J Hypertens. 2008 Jan; 26 (1): 124-129.
  • Is statin use associated with a reduced incidence, a reduced Breslow thickness or delayed metastasis of melanoma of the skin?.Abstract

    BACKGROUND: Statins show anticancer activity in melanoma cells. We investigated the association between statins and incidence and Breslow thickness of cutaneous melanoma (CM). METHODS: Data were used from PHARMO, a pharmacy database, and PALGA, a pthological database, in the Netherlands. Cases had a primary CM diagnosis between January 1st 1991 and December 14th 2004, were 18 years and had 3 years of follow up in PHARMO before CM diagnosis

    Koomen ER, Joosse A, Herings RM, Casparie MK, Bergman W, Nijsten T, Guchelaar HJ. Eur J Cancer. 2007 Nov; 43 (17): 2580-9.
  • Effect of drug combinations on admission for recurrent myocardial infarction.Abstract

    OBJECTIVE: To determine the effect of the number of different drugs with adherence to medication of at least 70% on recurrent admission for myocardial infarction (MI) in patients with a history of MI. DESIGN: Nested case-control study in a dynamicohort. SETTING: PHARMO database that contains pharmacy dispensing records and hospital discharge records of 350,000 Dutch citizens

    van der Elst ME, Bouvy ML, deBlaey CJ, deBoer A. Heart. 2007 Oct; 93 (10): 1226-30.
  • Use of beta-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands.Abstract

    Data from in vivo studies have indicated a role for beta-blockers in the prevention of bone loss. Some epidemiological studies have found protective effects of beta-blockers on fracture risk. However, there is limited information on the associationwith cumulative dose and type of beta-blockers used. We conducted two case-control studies using data from the UK General Practice Research Database (GPRD) and the Dutch PHARMO Record Linkage System (RLS)

    de Vries F, Souverein PC, Cooper C, Leufkens HG, van Staa TP. Calcif Tissue Int. 2007 Feb; 80 (2): 69-75.