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  • Characteristics of children and adolescents first prescribed proton pump inhibitors or histamine-2-receptor antagonists: an observational cohort studyAbstract

    OBJECTIVE: To describe the characteristics of pediatric patients prescribed proton pump inhibitors (PPIs) vs those of pediatric patients prescribed histamine-2-receptor antagonists (H2RAs). METHODS: Observational studies were conducted using The Helth Improvement Network (THIN) and the PHARMO Database Network

    Ruigomez A, Kool-Houweling LMA, Garcia Rodriguez LA, Penning-van Beest FJA, Herings RMC. Curr Med Res Opin. 2017 Jun 09; 33 2251-2259.
  • Pre- and post-diagnostic beta-blocker use and lung cancer survival: A population-based cohort studyAbstract

    Beta-blockers have been associated with decreased cancer mortality. However, evidence for lung cancer is sparse and reported beneficial effects might be based on biased analyses. In this so far largest study we investigated the association betweeneta-blocker use and lung cancer survival. Therefore, patients with a lung cancer diagnosis between April 1998 and December 2011 were selected from a database linkage of the Netherlands Cancer Registry and the PHARMO Database Network

    Weberpals J, Jansen L, Haefeli WE, Hoffmeister M, Wolkewitz M, Herk-Sukel Mppv, Vissers PAJ, Brenner H. Sci Rep. 2017 Jun 06; 7 2911.
  • Impact of detection bias on the risk of gastrointestinal cancer and its subsites in type 2 diabetes mellitusAbstract

    BACKGROUND: Type 2 diabetes mellitus (T2DM) may be a risk factor for gastrointestinal (GI) cancers, but variations in study designs of observational studies may have yielded biased results due to detection bias. Furthermore, differences in risk forGI cancer subsites have not been extensively evaluated

    deJong RGPJ, Burden AM, deKort S, van Herk-Sukel MPP, Vissers PAJ, Janssen PKC, Haak HR, Masclee AAM, deVries F, Janssen-Heijnen MLG. Eur J Cancer. 2017 Apr 29; 79 61-71.
  • Pre- and post-diagnostic beta-blocker use and prognosis after colorectal cancer: Results from a population-based studyAbstract

    Recent experimental and epidemiological studies have suggested that beta blocker use might be associated with better cancer prognosis, but results were inconclusive and only few studies have investigated the association specifically for colorectalancer (CRC) patients. We investigated this hypothesis using a linked dataset of the Eindhoven area of the Netherlands Cancer Registry and the PHARMO record linkage, including patients diagnosed with CRC between 1998 and 2011

    Jansen L, Weberpals J, Kuiper JG, Vissers PA, Wolkewitz M, Hoffmeister M, Brenner H. Int J Cancer. 2017 Apr 01; 62-71.
  • Psychiatric medication use before and after the onset of type 1 diabetes in children and adolescents: A population-based cohort studyAbstract

    BACKGROUND: Several studies showed a bidirectional association between type 2 diabetes and psychiatric disorders in adults. Because there is limited information on the association between type 1 diabetes (T1D) and psychiatric disorders (including pychiatric medication use) in children and adolescents, we assessed frequency of use of these medications before and after the onset of T1D

    FazeliFarsani S, Abdullah-Koolmees H, Souverein PC, de Boer A, Mantel-Teeuwisse AK. Pediatr Diabetes. 2017 Apr 24; 121 - 128.
  • Use of azithromycin and risk of ventricular arrhythmiaAbstract

    BACKGROUND: There are conflicting findings from observational studies of the arrhythrogenic potential of azithromycin. Our aim was to quantify the association between azithromycin use and the risk of ventricular arrhythmia. METHODS: We conducted aested case-control study within a cohort of new antibiotic users identified from a network of 7 population-based health care databases in Denmark, Germany, Italy, the Netherlands and the United Kingdom for the period 1997-2010

    Trifiro G, deRidder M, Sultana J, Oteri A, Rijnbeek P, Pecchioli S, Mazzaglia G, Bezemer I, Garbe E, Schink T, Poluzzi E, Froslev T, Molokhia M, Diemberger I, Sturkenboom Mcjm. CMAJ. 2017 Apr 18; 189 E560-E568.
  • Higher risk of colorectal cancer in patients with newly diagnosed diabetes mellitus before the age of colorectal cancer screening initiationAbstract

    Type 2 diabetes mellitus (T2DM) is associated with greater risk for colorectal cancer (CRC). The age of onset of T2DM is decreasing worldwide. An increased CRC risk in young T2DM patients could be relevant for the age at which to initiate CRC screeing. We report on CRC risk in T2DM patients with attention to age of diagnosis

    deKort S, Masclee AAM, Sanduleanu S, Weijenberg MP, van Herk-Sukel MPP, Olden hof NJJ, van den Bergh JPW, Haak HR, Janssen-Heijnen ML. Sci Rep. 2017 Apr 24; 7 46527.
  • Increased overall drug utilization in patients with psoriasis: a case-control study based on Dutch general practitioner dataAbstract

    BACKGROUND: Medication use in patients with psoriasis has been studied mostly in the context of psoriasis comorbidities. OBJECTIVES: To investigate detailed drug utilization in patients with psoriasis compared with controls in a population-based saple. METHODS: This was a case-control study based on drug prescriptions derived from a Dutch general practitioner database where patients with psoriasis and controls without psoriasis were matched 1 : 1 for age, sex, general practitioner and duration offollow-up, between 2002 and 2012

    Dowlatshahi EA, Hollestein LM, Herings RM, Nijsten T, Wakkee M. Br J Dermatol. 2017 Mar; 176 (3): 634-642.
  • Use of Lipid-Modifying Therapy and LDL-C Goal Attainment in a High-Cardiovascular-Risk Population in the NetherlandsAbstract

    PURPOSE: This study investigates lipid-modifying therapy (LMT) and LDL-C goal attainment in a real-world, high-cardiovascular-risk population in the Netherlands. METHODS: From the PHARMO Database Network, patients aged >/=18 years with an LDL-C meaurement in 2012 (index date) were selected and hierarchically classified into the following mutually exclusive high-cardiovascular-risk categories: familial hypercholesterolemia (FH), recent acute coronary syndrome (ACS), coronary heart disease, ischemicstroke, peripheral arterial disease, and diabetes mellitus

    Kuiper JG, Sanchez RJ, Houben E, Heintjes EM, Penning-van Beest FJ, Khan I, van Riemsdijk M, Herings RM. Clin Ther. 2017 Mar 24; 819 - 827.
  • No association between metformin use and survival in patients with pancreatic cancer: An observational cohort studyAbstract

    Several studies have suggested an association between use of metformin and an increased overall survival in patients diagnosed with pancreatic cancer, however with several important methodological limitations. The aim of the study was to assess theassociation between overall survival, pancreatic cancer, and metformin use

    Frouws MA, Mulder BG, Bastiaannet E, Zander s MM, van Herk-Sukel MP, deLeede EM, Bonsing BA, Mieog JS, VandeVelde CJ, Liefers GJ. Medicine (Baltimore). 2017 Mar; 96 (10): e6229.