Population-based cohort study of anti-infective medication use before and after the onset of type 1 diabetes in children and adolescents
A population-based cohort study was conducted in the Dutch PHARMO database to investigate prevalence and patterns of anti-infective medication use in children and adolescents with type 1 diabetes (T1D) before and after the onset of this disease. Alpatients <19 years with at least 2 insulin prescriptions (1999 to 2009) were identified (T1D cohort) and compared with an age- and sex-matched (ratio: 1 up to 4) diabetes-free reference group
Patterns of metachronous metastases after curative treatment of colorectal cancer
BACKGROUND: This study aimed to provide information on timing, anatomical location, and predictors for metachronous metastases of colorectal cancer based on a large consecutive series of non-selected patients. METHODS: All patients operated on withcurative intent for colorectal cancer (TanyNanyM0) between 2003 and 2008 in the Dutch Eindhoven Cancer Registry were included (N=5671)
Incident cancer risk after the start of aspirin use: results from a Dutch population-based cohort study of low dose aspirin users
Observational and intervention studies suggest that low dose aspirin use may prevent cancer. The objective of this study was to investigate the protective effect of long term low dose aspirin use (
Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon Cancer
IMPORTANCE Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is associated with improved overall survival. Identifying predictive biomarkers of this effect could individualize therapy and decrease toxic effects. OBJECIVE To demonstrate that survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer might depend on HLA class I antigen expression
Association between ADHD drug use and injuries among children and adolescents
To study the association between attention deficit hyperactivity disorder (ADHD) drug use and the incidence of hospitalization due to injuries. A random sample of 150,000 persons (0-18 years) was obtained from the Dutch PHARMO record linkage systemAn ADHD medication cohort as well as an up to six age/sex/index date sampled control cohort with no history of ADHD drug use was formed
Signal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database network
BACKGROUND: Data mining in spontaneous reporting databases has shown that drug-induced liver injury is infrequently reported in children. OBJECTIVES: Our objectives were to (i) identify drugs potentially associated with acute liver injury (ALI) inhildren and adolescents using electronic healthcare record (EHR) data; and (ii) to evaluate the significance and novelty of these associations
The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
BACKGROUND: Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Dveloping brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans
Disease history and medication use as risk factors for the clinical manifestation of type 1 diabetes in children and young adults: an explorative case control study
BACKGROUND: There is a highly variable asymptomatic period of beta cell destruction prior to the clinical presentation of type1 diabetes. It is not well known what triggers type 1 diabetes to become a clinically overt disease. This explorative studaimed to identify the association between disease history/medication use and the clinical manifestation of type 1 diabetes
Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study
BACKGROUND: To describe the utilisation of antibiotics in children and adolescents across 5 European countries based on the same drug utilisation measures and age groups. Special attention was given to age-group-specific distributions of antibioticsubgroups, since comparison in this regard between countries is lacking so far
Isotretinoin exposure during pregnancy: a population-based study in The Netherlands
OBJECTIVE: To estimate isotretinoin exposure in Dutch pregnant women despite the implemented pregnancy prevention programme (PPP) and second, to analyse the occurrence of adverse fetal or neonatal outcomes in these isotretinoin exposed pregnancies.DESIGN: Population-based study. SETTING: The Netherlands
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- Disease surveillance
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