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CNS diseases Publications

CNS diseases Publications

  • Antipsychotic drug use associated with urinary tract infections in older women.Abstract

    OBJECTIVES: Antipsychotic drugs are frequently prescribed to elderly patients, but they are associated with serious adverse effects. The objective of the current study was to investigate the association between use of antipsychotics by elderly womeand the risk of urinary tract infections (UTIs). COHORT STUDY SETTING: Dispensing data were obtained from the PHARMO Database Network for the period 1998-2008

    van Strien AM, Souverein PC, Keijsers CK, Heerdink ER, Derijks HJ, van Marum RJ. Maturitas. 2017 Apr; 98 46-50.
  • Prescribing pattern of antipsychotic drugs during the years 1996-2010: a population-based database study in Europe with a focus on torsadogenic drugs.Abstract

    INTRODUCTION: Antipsychotic drugs (APDs) are used to treat several mental illnesses. Some APDs have long been known to be associated with QT prolongation, potentially leading to torsades de pointes (TdP) and sudden cardiac death (SCD). In 2005, thiridazine was withdrawn because of the risk of SCD, bringing further attention to the arrhythmogenic potential of APDs

    Oteri A, Mazzaglia G, Pecchioli S, Molokhia M, Ulrichsen SP, Peder sen L, Poluzzi E, DePonti F, Garbe E, Schink T, Herings R, Bezemer ID, Sturkenboom MC, Trifiro G. Br J Clin Pharmacol. 2016 Aug; 82 487-97.
  • Post authorization safety study comparing quetiapine to risperidone and olanzapine.Abstract

    OBJECTIVES: To compare rates of specific adverse outcomes between patients starting quetiapine, olanzapine, or risperidone use in the Netherlands. METHODS: Observational study using the PHARMO Database Network, including patients starting quetiapin(4658), olanzapine (5856), or risperidone (7229) in 2000-2009, comparing rates of all-cause mortality, failed suicide attempts, extrapyrimidal symptoms (EPS), diabetes mellitus (DM), hypothyroidism, and acute myocardial infarction (AMI)

    Heintjes EM, Overbeek JA, Penning-van Beest FJ, Brobert G, Herings RM. Hum Psychopharmacol. 2016 Jul; 31 304-12.
  • Treatment with rivastigmine or galantamine and risk of urinary incontinence: results from a Dutch database study.Abstract

    BACKGROUND: Treatment of Alzheimer disease (AD) with cholinesterase inhibitors (ChEIs) may increase the risk of urinary incontinence (UI). OBJECTIVE: To assess whether ChEI use was associated with the risk of UI among older patients with AD. METHOD: A crossover cohort study using the PHARMO Record Linkage System included 10 years of data on drug dispensing histories for over two million Dutch residents

    Kroger E, VanMarum R, Souverein P, Carmichael PH, Egberts T. Pharmacoepidemiol Drug Saf. 2015 Mar; 24 276-85.
  • Association between ADHD drug use and injuries among children and adolescents.Abstract

    To study the association between attention deficit hyperactivity disorder (ADHD) drug use and the incidence of hospitalization due to injuries. A random sample of 150,000 persons (0-18 years) was obtained from the Dutch PHARMO record linkage systemAn ADHD medication cohort as well as an up to six age/sex/index date sampled control cohort with no history of ADHD drug use was formed

    van den Ban E, Souverein P, Meijer W, van Engeland H, Swaab H, Egberts T, Heerdink E. Eur Child Adolesc Psychiatry. 2014 Feb; 23 95-102.
  • The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design.Abstract

    BACKGROUND: Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Dveloping brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans

    Bottelier MA, Schouw ML, Klomp A, Tamminga HG, Schrantee AG, Bouziane C, de Ruiter MB, Boer F, Ruhe HG, Denys D, Rijsman R, Lindauer RJ, Reitsma HB, Geurts HM, Reneman L. BMC Psychiatry. 2014 14 48.
  • Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen.Abstract

    Tamoxifen is a largely inactive pro-drug, requiring metabolism into its most important metabolite endoxifen. Since the cytochrome P450 (CYP) 2D6 enzyme is primarily involved in this metabolism, genetic polymorphisms of this enzyme, but also drug-inuced CYP2D6 inhibition can result in considerably reduced endoxifen formation and as a consequence may affect the efficacy of tamoxifen treatment

    Binkhorst L, Mathijssen RH, van Herk-Sukel MP, Bannink M, Jager A, Wiemer EA, van Gelder T. Breast Cancer Res Treat. 2013 Jun; 139 923-9.
  • Use of rivastigmine or galantamine and risk of adverse cardiac events: a database study from the Netherlands.Abstract

    BACKGROUND: Two cholinesterase inhibitors (ChEIs), rivastigmine and galantamine, are used to treat Alzheimer disease in the Netherlands. Several adverse cardiac events have been reported for these medications. OBJECTIVE: We aimed to assess if the ue of ChEIs increased the risk of cardiac events in the Netherlands

    Kroger E, Berkers M, Carmichael PH, Souverein P, van Marum R, Egberts T. Am J Geriatr Pharmacother. 2012 Dec; 10 373-80.
  • Risk of fractures in patients with multiple sclerosis: a population-based cohort study.Abstract

    OBJECTIVE: To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls. METHODS: A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998-2008). Patients withMS (n = 2,415) were matched by year of birth, sex, and practice to up to 6 patients without MS (controls)

    Bazelier MT, van Staa TP, Uitde haag BM, Cooper C, Leufkens HG, Vestergaard P, Herings RM, de Vries F. Neurology. 2012 Jun 12; 78 1967-73.
  • Differences in lithium use patterns in the Netherlands: comparing middle-aged and older patients in a database study.Abstract

    BACKGROUND: Age-dependent changes in lithium pharmacokinetic and pharmacodynamic properties can influence lithium use in an aging population, especially as newer treatment options are available. OBJECTIVE: We compared lithium use patterns between mddle-aged and elderly outpatients in the Netherlands

    van Melick EJ, Wilting I, Souverein PC, Egberts TC. Am J Geriatr Pharmacother. 2012 Jun; 10 193-200.