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  • The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and designAbstract

    BACKGROUND: Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Dveloping brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans

    Bottelier MA, Schouw ML, Klomp A, Tamminga HG, Schrantee AG, Bouziane C, de Ruiter MB, Boer F, Ruhe HG, Denys D, Rijsman R, Lindauer RJ, Reitsma HB, Geurts HM, Reneman L. BMC Psychiatry. 2014 14 48.
  • Disease history and medication use as risk factors for the clinical manifestation of type 1 diabetes in children and young adults: an explorative case control studyAbstract

    BACKGROUND: There is a highly variable asymptomatic period of beta cell destruction prior to the clinical presentation of type1 diabetes. It is not well known what triggers type 1 diabetes to become a clinically overt disease. This explorative studaimed to identify the association between disease history/medication use and the clinical manifestation of type 1 diabetes

    FazeliFarsani S, Souverein PC, van der Vorst MM, Mantel-Teeuwisse AK, Knibbe CA, deBoer A. PLoS One. 2014 9 e87408.
  • Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort studyAbstract

    BACKGROUND: To describe the utilisation of antibiotics in children and adolescents across 5 European countries based on the same drug utilisation measures and age groups. Special attention was given to age-group-specific distributions of antibioticsubgroups, since comparison in this regard between countries is lacking so far

    Holstiege J, Schink T, Molokhia M, Mazzaglia G, Innocenti F, Oteri A, Bezemer I, Poluzzi E, Puccini A, Ulrichsen SP, Sturkenboom MC, Trifiro G, Garbe E. BMC Pediatr. 2014 14 174.
  • Isotretinoin exposure during pregnancy: a population-based study in The NetherlandsAbstract

    OBJECTIVE: To estimate isotretinoin exposure in Dutch pregnant women despite the implemented pregnancy prevention programme (PPP) and second, to analyse the occurrence of adverse fetal or neonatal outcomes in these isotretinoin exposed pregnancies.DESIGN: Population-based study. SETTING: The Netherlands

    Zomerdijk IM, Ruiter R, Houweling LM, Herings RM, Sturkenboom MC, Straus SM, Stricker BH. BMJ Open. 2014 4 e005602.
  • beta-Blocker use and all-cause mortality of melanoma patients: results from a population-based Dutch cohort studyAbstract

    BACKGROUND: Results from preclinical and observational studies suggest that beta-adrenoreceptor inhibition might influence disease progression of melanoma. PATIENTS AND METHODS: Patients 18years with cutaneous melanoma (Breslow thickness >1mm) regitered in the Eindhoven Cancer Registry between January 1, 1998 and December 31, 2010, who were also registered with PHARMO record linkage system (RLS), were eligible

    Livingstone E, Hollestein LM, van Herk-Sukel MP, van dePoll-Franse L, Nijsten T, Schaden dorf D, deVries E. Eur J Cancer. 2013 Dec; 49 3863-71.
  • Persisting gender differences and attenuating age differences in cardiovascular drug use for prevention and treatment of coronary heart disease, 1998-2010Abstract

    BACKGROUND: Evidence on recent time trends in age-gender differences in cardiovascular drug use is scarce. We studied time trends in age-gender-specific cardiovascular drug use for primary prevention, secondary prevention, and in-hospital treatmentof coronary heart disease. METHODS AND RESULTS: The PHARMO database was used for record linkage of drug dispensing, hospitalization, and population data to identify drug use between 1998 and 2010 in 1 203 290 persons >/=25 years eligible for primary prevention, 84 621 persons hospitalized for an acute coronary syndrome (ACS), and 15 651 persons eligible for secondary prevention

    Koopman C, Vaartjes I, Heintjes EM, Spiering W, van Dis I, Herings RM, Bots ML. Eur Heart J. 2013 Nov; 34 3198-205.
  • Replication of the OMOP Experiment in Europe: Evaluating Methods for Risk Identification in Electronic Health Record DatabasesAbstract

    BACKGROUND: The Observational Medical Outcomes Partnership (OMOP) has just completed a large scale empirical evaluation of statistical methods and analysis choices for risks identification in longitudinal observational healthcare data. This experimnt drew data from four large US health insurance claims databases and one US electronic health record (EHR) database, but it is unclear to what extend the findings of this study apply to other data sources

    Schuemie MJ, Gini R, Coloma PM, Straatman H, Herings RM, Peder sen L, Innocenti F, Mazzaglia G, Picelli G, van der Lei J, Sturkenboom MC. Drug Saf. 2013 Oct; 36 Suppl 1 159-69.
  • Pulmonary embolism, myocardial infarction, and ischemic stroke in lung cancer patients: results from a longitudinal studyAbstract

    PURPOSE: In this cohort study, the rates of pulmonary embolism (PE), myocardial infarction (MI), and ischemic stroke (IS) before and after lung cancer (LC) diagnosis were compared to cancer-free controls. METHODS: Patients with LC during 2000-2007ere selected from PALGA, the Dutch Pathology Registry, and linked to the PHARMO medical record linkage system, including drug use and hospitalizations of 3 million inhabitants in the Netherlands

    van Herk-Sukel MP, Shantakumar S, Penning-van Beest FJ, Kamphuisen PW, Majoor CJ, Overbeek LI, Herings RM. Lung. 2013 Oct; 191 501-9.
  • Increased Antidepressant Drug Exposure in Psoriasis Patients: A Longitudinal Population-based Cohort StudyAbstract

    Psoriasis has a major impact on health-related quality of life. The present cohort study investigated the use of antidepressant drugs in psoriasis patients and a reference cohort, using pharmacy and hospitalization data from 1998 to 2008 for more tan 2.5 million Dutch residents. Multivariate Cox regression was used to compare the risk of first antidepressant use, and Poisson regression to compare the number of episodes of antidepressant use

    Dowlatshahi EA, Wakkee M, Herings RM, Hollestein LM, Nijsten T. Acta Derm Venereol. 2013 Sep 4; 93 544-50.
  • Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary careAbstract

    PURPOSE: To determine whether treatment with nitrofurantoin in women with urinary tract infection (UTI) and renal impairment in primary care is associated with a higher risk of ineffectiveness and/or serious adverse events than in women without renl impairment. METHODS: A cohort of 21,317 women treated with nitrofurantoin and a cohort of 7,926 women treated with trimethoprim, identified from the Pharmo Record Linkage System, were analysed

    Geerts AF, Eppenga WL, Heerdink R, Derijks HJ, Wensing MJ, Egberts TC, DeSmet PA. Eur J Clin Pharmacol. 2013 Sep; 69 1701-7.