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  • The Epidemiology of Hip and Major Osteoporotic Fractures in a Dutch Population of Community-Dwelling Elderly: Implications for the Dutch FRAX(R) AlgorithmAbstract

    BACKGROUND: Incidence rates of non-hip major osteoporotic fractures (MOF) remain poorly characterized in the Netherlands. The Dutch FRAX(R) algorithm, which predicts 10-year probabilities of hip fracture and MOF (first of hip, humerus, forearm, cliical vertebral), therefore incorporates imputed MOF rates

    Klop C, Welsing PM, Leufkens HG, Elder s PJ, Overbeek JA, van den Bergh JP, Bijlsma JW, deVries F. PLoS One. 2015 10 e0143800.
  • Using real-world healthcare data for pharmacovigilance signal detection – the experience of the EU-ADR projectAbstract

    A prospective pharmacovigilance signal detection study, comparing the real-world healthcare data (EU-ADR) and two spontaneous reporting system (SRS) databases, US FDA’s Adverse Event Reporting System and WHO’s Vigibase is reported. The study compard drug safety signals found in the EU-ADR and SRS databases

    Patadia VK, Coloma P, Schuemie MJ, Herings R, Gini R, Mazzaglia G, Picelli G, Fornari C, Peder sen L, van der Lei J, Sturkenboom M, Trifiro G, consortium Eu-Adr. Expert Rev Clin Pharmacol. 2015 Jan; 8 95-102.
  • Statin use and its effect on all-cause mortality of melanoma patients: a population-based Dutch cohort studyAbstract

    Preclinical data showed anticancer effects of statins in melanoma, but meta-analyses could not demonstrate a reduced melanoma incidence in statin users. Rather than preventing occurrence, statins might reduce growth and metastatic spread of melanoms and ultimately improve survival. In this population-based study, we investigated the relationship between statin use and survival of melanoma patients

    Livingstone E, Hollestein LM, van Herk-Sukel MP, van dePoll-Franse L, Joosse A, Schilling B, Nijsten T, Schaden dorf D, deVries E. Cancer Med. 2014 Oct; 3 1284-93.
  • Risk of upper gastrointestinal bleeding from different drug combinationsAbstract

    BACKGROUND & AIMS: Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known abouthe magnitude of their interactions. We estimated the risk of UGIB during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inhibitors (COX-2 inhibitors), and low-dose aspirin with other drugs

    Masclee GM, Valkhoff VE, Coloma PM, deRidder M, Romio S, Schuemie MJ, Herings R, Gini R, Mazzaglia G, Picelli G, Scotti L, Peder sen L, Kuipers EJ, van der Lei J, Sturkenboom MC. Gastroenterology. 2014 Oct; 147 784-792 e9.
  • Population-based cohort study of anti-infective medication use before and after the onset of type 1 diabetes in children and adolescentsAbstract

    A population-based cohort study was conducted in the Dutch PHARMO database to investigate prevalence and patterns of anti-infective medication use in children and adolescents with type 1 diabetes (T1D) before and after the onset of this disease. Alpatients <19 years with at least 2 insulin prescriptions (1999 to 2009) were identified (T1D cohort) and compared with an age- and sex-matched (ratio: 1 up to 4) diabetes-free reference group

    FazeliFarsani S, Souverein PC, van der Vorst MM, Knibbe CA, deBoer A, Mantel-Teeuwisse AK. Antimicrob Agents Chemother. 2014 Aug; 58 4666-74.
  • Patterns of metachronous metastases after curative treatment of colorectal cancerAbstract

    BACKGROUND: This study aimed to provide information on timing, anatomical location, and predictors for metachronous metastases of colorectal cancer based on a large consecutive series of non-selected patients. METHODS: All patients operated on withcurative intent for colorectal cancer (TanyNanyM0) between 2003 and 2008 in the Dutch Eindhoven Cancer Registry were included (N=5671)

    van Gestel YR, de Hingh IH, van Herk-Sukel MP, van Erning FN, Beerepoot LV, Wijsman JH, Slooter GD, Rutten HJ, Creemers GJ, Lemmens VE. Cancer Epidemiol. 2014 Aug; 38 448-54.
  • Incident cancer risk after the start of aspirin use: results from a Dutch population-based cohort study of low dose aspirin usersAbstract

    Observational and intervention studies suggest that low dose aspirin use may prevent cancer. The objective of this study was to investigate the protective effect of long term low dose aspirin use (

    Hollestein LM, van Herk-Sukel MP, Ruiter R, de Vries E, Mathijssen RH, Wiemer EA, Stijnen T, Coebergh JW, Lemmens VE, Herings RM, Stricker BH, Nijsten T. Int J Cancer. 2014 Jul 1; 135 157-65.
  • Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon CancerAbstract

    IMPORTANCE Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is associated with improved overall survival. Identifying predictive biomarkers of this effect could individualize therapy and decrease toxic effects. OBJECIVE To demonstrate that survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer might depend on HLA class I antigen expression

    Reimers MS, Bastiaannet E, Langley RE, van Eijk R, van Vlierberghe RL, Lemmens VE, van Herk-Sukel MP, van Wezel T, Fodde R, Kuppen PJ, Morreau H, van de Velde CJ, Liefers GJ. JAMA Intern Med. 2014 May 1; 174 732-9.
  • Association between ADHD drug use and injuries among children and adolescentsAbstract

    To study the association between attention deficit hyperactivity disorder (ADHD) drug use and the incidence of hospitalization due to injuries. A random sample of 150,000 persons (0-18 years) was obtained from the Dutch PHARMO record linkage systemAn ADHD medication cohort as well as an up to six age/sex/index date sampled control cohort with no history of ADHD drug use was formed

    van den Ban E, Souverein P, Meijer W, van Engeland H, Swaab H, Egberts T, Heerdink E. Eur Child Adolesc Psychiatry. 2014 Feb; 23 95-102.
  • Signal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database networkAbstract

    BACKGROUND: Data mining in spontaneous reporting databases has shown that drug-induced liver injury is infrequently reported in children. OBJECTIVES: Our objectives were to (i) identify drugs potentially associated with acute liver injury (ALI) inhildren and adolescents using electronic healthcare record (EHR) data; and (ii) to evaluate the significance and novelty of these associations

    Ferrajolo C, Coloma PM, Verhamme KM, Schuemie MJ, deBie S, Gini R, Herings R, Mazzaglia G, Picelli G, Giaquinto C, Scotti L, Avillach P, Peder sen L, Rossi F, Capuano A, van der Lei J, Trifiro G, Sturkenboom MC, consortium Eu-Adr. Drug Saf. 2014 Feb; 37 99-108.