Menumenu

Pharmacoepidemiology

In our pharmacoepidemiologal studies we seek to broaden the knowledge and science underlying post-marketing drug surveillance (studies conducted after a medicine has been released into the market) and disease surveillance. We bridge the gap between the information generated by pre-marketing clinical trials and the real world drug usage. Effectiveness and safety of drugs are thoroughly studied in randomised clinical trials. However, few data are available on these parameters in everyday clinical practice. The effectiveness and utilisation of drugs may be different than expected as daily practice differs from the experimental setting with respect to the heterogeneity of patients, their age, treatments and co-morbidity. Moreover, important safety issues may not be detectable in clinical trials because the frequency of many adverse events is low and adverse effects may occur many years after drug administration (van Herk, Pharmacoepi Drug Saf 2012). Disease surveillance studies are used to create insight in the presence of the disease in a population-based sample.

The PHARMO team has over 15 years of experience in performing pharmacoepidemiological research. In our pharmacoepidemiological research we study the use and effects, both beneficial and adverse, of medicines in well-defined populations. The PHARMO Database Network has proven to be rich source of information for this type of research.

We have delivered our tailor-made services for more than 600 late-phase studies and 300 publications in the last 15 years across a wide range of therapeutic areas, including diabetes, cardiovascular diseases, respiratory diseases, oncology, and women’s health and paediatrics. Our internal standardised procedures and quality guidelines are in accordance with the ENCePP Guide on Methodological Standards in Pharmacoepidemiology and the ENCePP Code of Conduct to guarantee high quality services. This Code should not be considered as a stand-alone document but should be read in conjunction with other relevant guidance such as Good Pharmacoepidemiology Practices of the International Society of Pharmacoepidemiology.

If you are looking for a broad range of consultancy and research services to match your pharmacoepidemiology needs, please contact us